ID G1PC50_MYOLU Unreviewed; 1083 AA.
AC G1PC50;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Caprin family member 2 {ECO:0000313|Ensembl:ENSMLUP00000007980.2};
GN Name=CAPRIN2 {ECO:0000313|Ensembl:ENSMLUP00000007980.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000007980.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000007980.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000007980.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the caprin family.
CC {ECO:0000256|ARBA:ARBA00007950}.
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DR EMBL; AAPE02013517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PC50; -.
DR STRING; 59463.ENSMLUP00000007980; -.
DR Ensembl; ENSMLUT00000008758.2; ENSMLUP00000007980.2; ENSMLUG00000008734.2.
DR eggNOG; ENOG502QQ53; Eukaryota.
DR GeneTree; ENSGT00940000153438; -.
DR HOGENOM; CLU_009305_0_0_1; -.
DR InParanoid; G1PC50; -.
DR OMA; NHNQHGE; -.
DR TreeFam; TF329471; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0061003; P:positive regulation of dendritic spine morphogenesis; IEA:Ensembl.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR028816; Caprin.
DR InterPro; IPR022070; Caprin-1_C.
DR InterPro; IPR041637; Caprin-1_dimer.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR22922:SF5; CAPRIN-2; 1.
DR PANTHER; PTHR22922; GPI-ANCHORED PROTEIN P137; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF12287; Caprin-1_C; 1.
DR Pfam; PF18293; Caprin-1_dimer; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Protein synthesis inhibitor {ECO:0000256|ARBA:ARBA00023193};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 949..1083
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 20..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 88..156
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1083 AA; 120571 MW; 2250191B3FE84ADD CRC64;
LILNFPPLPP SGSAVSMVQF SSSPFGHQSP SGHSEEGREG TMKSAKPQVN HSLGESQRAL
SPLQSPLRSA ASPSQAYETY IDNGLICLKH KIRNIEKKKL KLEDYKDRLK NGEQLNPDQL
EAVEKYEEVL HNLEFAKELQ KTFSGLSQDL LKAQKKAQRR EHMLKLEAEK KKLCTVLQLQ
YVLQNLTQEH VQKDLKEGLN GAVCLPLKEL DYLIKFSKLT CPERNESLSV EDQMEQSSLY
FWDLLEGSEK AVVGTTYKHM KELLSKLLNS GYFESIPVPK SAQEKEVSLE EEIKSEKRKL
LLKTESVRES ESLMEFTQTE IQPQEFLNRR YIAEVDYSSK QHDEQSWEAD YARKPNLPKC
WDKLTEPAGE EKKQESFRSW EPSVKQQELA RPAVSSEQRK QEMAKLRSTL QEEQKKQDVS
KPKLTPSQWK QETPKPKAGC VQEEQKKQET PRPWPVQLQK EQDPKKQTAK SWTPSLQSEQ
DLSKSWAAPM CEEQDARQAE TPKSWDNNVE HPKHPLTPQS QTSPKSWGVA AGSLIPNDQL
LPRKFNAEPK DVPKPMHQPV GSSSPLPKDP VLRKEKLQDL MTQIQGTCNF MQESILDFDK
PSSAIPSSQL PSVTPGSPAA TTEQNLTSQN DFLQEPSQTA VSPVTSSSSA CLVTTDQASS
GSETEFMPTE TPEAAVPPSK QPSSLASPNS PMSKGPEQGF PSPPATSSSV TIGTAPFQAM
QTVFNVNAPL PPRKEQEIKE STCSPGYNQS FTTASTQTPL QCQLPAIHVE QTVLSQETAA
SYPDGTIQVS NGSLAFYPAQ TNVFPRPSQP FVNSRGSVRG CTRGGRLLTN TYRSPGAYKG
FDTYRGPPSV SNGNYSQLQF QAREYPGTPY SQRDNFQQCY KRGGTSGGPR ANSRAGWSDS
SQVSSPERDS ETFNSGDSGQ GDSRSMTPVD VPVTNPAATI LPVHVYPLPQ QMRVAFSAAR
TSNLAPGTLD QPIVFDLLLN NLGETFDLQL GRFNCPVNGT YVFIFHMLKL AVNVPLYVNL
MKNEEVLVSA YANDGAPDHE TASNHAILQL FQGDQIWLRL HRGAIYGSSW KYSTFSGYLL
YQD
//
