ID G1PCQ7_MYOLU Unreviewed; 937 AA.
AC G1PCQ7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Integrin subunit alpha 11 {ECO:0000313|Ensembl:ENSMLUP00000008213.2};
GN Name=ITGA11 {ECO:0000313|Ensembl:ENSMLUP00000008213.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000008213.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000008213.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000008213.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AAPE02041957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02041958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02041959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PCQ7; -.
DR STRING; 59463.ENSMLUP00000008213; -.
DR Ensembl; ENSMLUT00000009013.2; ENSMLUP00000008213.2; ENSMLUG00000008993.2.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000155465; -.
DR HOGENOM; CLU_004111_2_1_1; -.
DR InParanoid; G1PCQ7; -.
DR OMA; HGIGPPF; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0034681; C:integrin alpha11-beta1 complex; IEA:Ensembl.
DR GO; GO:0098639; F:collagen binding involved in cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0038064; F:collagen receptor activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006929; P:substrate-dependent cell migration; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 891..915
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 1..98
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 104..155
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 211..276
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 277..335
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 339..399
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 937 AA; 105391 MW; 6B01088301F6DE4F CRC64;
SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIQQSERD NVTRYAVAVL GYYNRRGINP
ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDAGDRIFS LEGTNKNETS FGLEMSQTGF
SSHVVEDGIL LGAVGAYDWN GAVLKETSGG KVIPLRESYL KEFPEELRNH GAYLGYTVTS
VVSSRQGRVY VAGAPRFNHT GKAILFTMHN NRSLTIHQAL RGEQIGSYYG SEITAVDIDG
DGVTDVLLVG APMYFSEGRE RGRVYVYNLR QNRFVYNGTL QDSHSYQNAR FGASIAWVRD
LNQDSYNDVV VGAPLEDNHE GAIYIFHGFR GSLLKTPKQR IAASELAPGL QYFGCSIHGQ
LDLNEDGLVD LAVGALGNAV ILWSRPVVQI NASLHFEPPK INIFHRDCKR SGRDATCLAA
FLCFTPVFLA PHFQTATVGK HQVQCTMDER RYTRAHLDEG GDRYTNRAVL LSSGQEHCDR
ISFHVLDTAD YVKPVTFSVE YSLEDPDHGP MLDDGWPTTL RVSVPFWNGC NEDEHCVPDL
LLDARSDLPT AMEYCQRVLR KPAQDCSAYT LSFDTTVFII ESTRRRVAVE AMLENRGENA
YSTVLNISQS ANLQFASLIQ REDSDGSIEC VNEERRLHKK VCNVSYPFFR AKAKVAFRLD
FEFSKSVFLH HLEVQLTAGS DSDEEESTKE DNAALLRFHL KYEADILFTR SSSLSHYEVK
PNSSLESYNG IGPPFHCIFK IQNLGLFPIH GVMMKITVPI ATRSGNRLLM LRDFLTDQVN
TSCNVWGNST EYRHSPMEED LSRTPQLNHS NSDVVSINCH VRLAPNQEIN FHLLGNLWLR
SLKALKYKLM KITVHAAVQR QFHSPFIFRE EDPSRQITFE ISKQEDWQIP IWIIVGSTLG
GLLLLALLVL ALWKLGFFKS AKRRREPGLD PTPKALE
//
