ID G1PD51_MYOLU Unreviewed; 1232 AA.
AC G1PD51;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Cullin-associated NEDD8-dissociated protein 1 {ECO:0000256|ARBA:ARBA00040131};
DE AltName: Full=Cullin-associated and neddylation-dissociated protein 1 {ECO:0000256|ARBA:ARBA00042178};
GN Name=CAND1 {ECO:0000313|Ensembl:ENSMLUP00000008375.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000008375.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000008375.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000008375.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CAND family.
CC {ECO:0000256|ARBA:ARBA00007657}.
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DR EMBL; AAPE02035028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02035029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02035030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PD51; -.
DR STRING; 59463.ENSMLUP00000008375; -.
DR Ensembl; ENSMLUT00000009188.2; ENSMLUP00000008375.2; ENSMLUG00000009166.2.
DR eggNOG; KOG1824; Eukaryota.
DR GeneTree; ENSGT00390000017740; -.
DR HOGENOM; CLU_007157_0_0_1; -.
DR InParanoid; G1PD51; -.
DR OMA; XQGGLLV; -.
DR TreeFam; TF300355; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0010265; P:SCF complex assembly; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039852; CAND1/CAND2.
DR InterPro; IPR013932; TATA-bd_TIP120.
DR PANTHER; PTHR12696:SF1; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR12696; TIP120; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF08623; TIP120; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1042..1204
FT /note="TATA-binding protein interacting (TIP20)"
FT /evidence="ECO:0000259|Pfam:PF08623"
FT REGION 317..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..344
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 136831 MW; 2F1BF81E2FA59A8C CRC64;
MASASYHISN LLEKMTSSDK DFRFMATNDL MTELQKDSIK LDDDSERKVV KMILKLLEDK
NGEVQNLAVK CLGPLVSKVK RYQVETLVDT LCTNHAFKEQ LRDISGGREV SIKKIFGNHP
FEQAGSALAA NVCKKITGRL TSAIAKQEDV SVQLEALDIM ADMLSRQGGL LVNFHPSILT
CLLPQLTSPR LAVRKRTIIA LGHLVMSCGN IVFVDLIEHL LSELSKNDSM STTRTYIQCI
AAISRQAGHR IGEYLEKIIP LVVKFCNVDD DELREYCIQA FESFVRRCPK EVYPHVSTII
NICLKYLTYD PNYNYDDEDE DENAMDADGG DDDDQGSDDE YSDDDDMSWK VRRAAAKCLD
AVVSTRHEML AEFYKTVSPA LISRFKEREE NVKADVFHAY LSLLKQTRPV QSWLCDPDAM
EQGETPLTML QSQVPNIVKA LHKQMKEKSV KTRQCCFNML TELVNVLPGA LTQHIPVLVP
GIIFSLNDKS SSSNLKIDAL SCLYVILCNH SPQVFHPHVQ ALVPPVVACV GDPFYKITSE
ALLVTQQLVK VIRPLDQPSS FDATPYIKDL FTCTIKRLKA ADIDQEVKER AISCMGQIIC
NLGDNLGSDL PNTLQIFLER LKNEITRLTT VKALTLIAGS PLKIDLRPVL GEGVPILASF
LRKNQRALKL GTLSALDILI KNYSDSLTAA MIDAVLDELP PLISESDMHV SQMAISFLTT
LAKVYPSSLS KISGSILNEL IGLVRSPLLQ GGALSAMLDF FQALVVTGTN NLGYMDLLRM
LTGPVYSQST ALTHKQSYYS IAKCVAALTR ACPKEGPAVV GQFIQDVKNS RSTDSIRLLA
LLSLGEVGHH IDLSGQLELK SVILEAFSSP SEEVKSAASY ALGSISVGNL PEYLPFVLQE
ITSQPKRQYL LLHSLKEIIS SASVVGLKPY VENIWALLLK HCECAEEGTR NVVAECLGKL
TLIDPETLLP RLKGYLISGS SYARSSVVTA VKFTISDHPQ PIDPLLKNCI GDFLKTLEDP
DLNVRRVALV TFNSAAHNKP SLIRDLLDTV LPHLYNETKV RKELIREVEM GPFKHTVDDG
LDIRKAAFEC MYTLLDSCLD RLDIFEFLNH VEDGLKDHYD IKMLTFLMLV RLSTLCPSAV
LQRLDRLVEP LRATCTTKVK ANSVKQEFEK QDELKRSAMR AVAALLTIPE AEKSPLMSEF
QSQISSNPEL AAIFESIQKD SSSTNLESMD TS
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