ID G1PEK3_MYOLU Unreviewed; 788 AA.
AC G1PEK3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=MEFV innate immuity regulator, pyrin {ECO:0000313|Ensembl:ENSMLUP00000008951.2};
GN Name=MEFV {ECO:0000313|Ensembl:ENSMLUP00000008951.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000008951.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000008951.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000008951.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02021022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PEK3; -.
DR STRING; 59463.ENSMLUP00000008951; -.
DR Ensembl; ENSMLUT00000009819.2; ENSMLUP00000008951.2; ENSMLUG00000009793.2.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000161955; -.
DR HOGENOM; CLU_016050_0_0_1; -.
DR InParanoid; G1PEK3; -.
DR OMA; CQRHMKQ; -.
DR TreeFam; TF351091; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:Ensembl.
DR GO; GO:0005875; C:microtubule associated complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0071641; P:negative regulation of macrophage inflammatory protein 1 alpha production; IEA:Ensembl.
DR GO; GO:1900226; P:negative regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:1904270; P:pyroptosome complex assembly; IEA:Ensembl.
DR GO; GO:0034341; P:response to type II interferon; IEA:Ensembl.
DR CDD; cd19771; Bbox2_TRIM20; 1.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR CDD; cd15813; SPRY_PRY_TRIM20; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF606; PYRIN; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF02758; PYRIN; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM01289; PYRIN; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 382..419
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 587..782
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 97..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 87846 MW; A536DE7A036D8AB4 CRC64;
MAKTPSDYLL HSLEELVPYD FEKFKFKLQN TSLEKEQQRI PRGLLPSARP VKLADLLLNH
YGEKYAVQLT LQILRAMNQH LLAEELHRAI DPEYPIQESG TDCPAMSCSS GENKPKSLKM
PDGLEGDRQQ QSGDGAASQP EAGKGPQKKP QGKRRDQKGS EGLDVQGKPG ARGGTLCSRR
SPLPSKQPGE KGSDSSVRLR RNASSAGRLQ GLSSGSYAGS LGRKASEARS PSKKNRPRSL
EFTISSRERA LSNLETLLPQ EKVRSENLDS SATPSKVATL DAGATMAVEK GSRNPEHSVT
RRPQDEAVCP LSRAQEGDLV GSTCVRDSGS CSIASKDPKA SDGCLPNCLR CQVSLPGKSS
GGIEPQEGPP MGSLSPTLQP QCTRHRKQVQ LLFCEDHREP ICLICSLSQE HRGHRVRPIE
EAALEYKEQI QKELEHLKAL RRSGEEQRSE GDKNTANYLK QTEIQKQRVR CQMEQLCRFL
EQQERLFVAW LEKLAQTIVQ VGETYDTQVS RDIALLTELI EELETKQRQP EWELMQDIGV
TLRRVKTVTV PEPWATPLEV KEKIHLLLQK SEFVEKSMKH FSGTLRSEME TFNVPELIDA
QTHAVNVVLD AETAHPNLII SDDLKSARLG NKWIHMPDSP ERFDSCIFAL GSPSFRSGRH
YWEVEVGDKT GWVLGICKAS TSRKGNMTLS PENGYWVVMM MKRNEYQAST FPPTRLRMRE
PPRRVGIFLD YKAGDISFYN VTAKSHIYTF TSFSFSGPLQ AIFSPGTHDG GKNMDPLTIC
PVGDQGPH
//
