ID G1PGX8_MYOLU Unreviewed; 1157 AA.
AC G1PGX8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Solute carrier family 9 member C1 {ECO:0000313|Ensembl:ENSMLUP00000009910.2};
GN Name=SLC9C1 {ECO:0000313|Ensembl:ENSMLUP00000009910.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009910.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000009910.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000009910.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02028785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02028786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02028787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02028788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02028789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PGX8; -.
DR STRING; 59463.ENSMLUP00000009910; -.
DR Ensembl; ENSMLUT00000010871.2; ENSMLUP00000009910.2; ENSMLUG00000010824.2.
DR eggNOG; KOG1965; Eukaryota.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000162055; -.
DR HOGENOM; CLU_003400_1_0_1; -.
DR InParanoid; G1PGX8; -.
DR OMA; RVVTFDC; -.
DR TreeFam; TF328865; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF87; SODIUM_HYDROGEN EXCHANGER 10; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 41..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 924..995
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 1157 AA; 133305 MW; E54365D915D1C53E CRC64;
VRTNRMSMNL STTNYTFHNK GFSGSWVEFV KNKFNTYPQD LPEIILILAL ICTIGAILNL
HLKDFIIPLP VILFLIGCSF EILSFASDQV CIVLRYAHAI QWMDSQLFYY LFTPVIIFNV
AFDMDVYMFQ KLFWQIILIT IPGCFINYTL ILWYLTSMNK LRLKTTPWLL FASILMSSDP
MLTAAAVRDL GLSRGLINLI NGESLVTSIM SYNMFASIMD FNTDQKSMNH SLARSIVSPI
LSYYLSSFLF GILSAKLVHL WMSTVFGDDI NHISLNFSNM YLIFFICKIG ELVGMSGVFT
LAIMGLFLNS TSLKPGVESL LLEKCRFWNC LAFVAFLMVF TFIGLLIPAH TYLYVSFSDI
YYSLNIYFTL IVLRLLVFLL LSPLLSRLGD GFSWRWAFIM VWSEMRGLPN VTMALLLAYS
DLSVGTEREK SQVLFHGVSV CLITLIVNRI ILPMVVSKLG LRDVTSTKYK SLYYTFQHFQ
EITKSAASAL KFDKDLANAD WNMVEKAIIF QNPYALSQGE TTEHQKVNCP NCKTEINETL
NIEAMELANR RILSAQIASY QRQYRNESLS QSAVQMLVGA AGSFGEKGEY MSLETIKNYS
ESKTILTFVR KVLLNWVYNT KKEKGIPSRR YCFLNVFHKI VFTDEFEYVG YLVILMNTFP
IIISWMPTIY YTYDDELRQA NYVFMGFYIL ECLVKIAAMR KEYFLHAWNL FELVIALIGI
VDVIIVEAES IYNIFDLDEI VVFFKAIRLL RILRILKLIT PKLLQFIDKR MSHQLSYKYA
ILKGYVQGEA DIMTIIDQIA SSKQVKQVLL KRITRNTVHA LKELGYLEYD HPEIAVTMKT
KEEINVMLSL AREIVRVFRL RGILHKIEAN EINKLIMDKK RELLDFEPIV KSLTLTEALY
HIPWLDKNSD HINFIQEKAK LITFDCGNTI FEEGDETLGI YVIISGMIKL QRSKSGLMAD
QLLSESEGKD NQIIFTDYVI SGETIGELNC LTNEPMKYSA ICKTVVETCF IPKSHLYDAF
EYLSPDIEYK MWLKLGLSIT AQKIREHLSY EDWTYKMQLK LSNVYVKDIP KSTKCDIYDE
HVIYVILIHG AVEDCHLRKA YKAPSSIPLT CHQIQGTENF TKVMIVQTSI DTKKFRWKTK
KFVPLLKSSV PGEQECE
//
