ID G1PH01_MYOLU Unreviewed; 451 AA.
AC G1PH01;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Perilipin {ECO:0000256|PIRNR:PIRNR036881};
GN Name=PLIN2 {ECO:0000313|Ensembl:ENSMLUP00000009934.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009934.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000009934.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000009934.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the perilipin family.
CC {ECO:0000256|ARBA:ARBA00006311, ECO:0000256|PIRNR:PIRNR036881}.
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DR EMBL; AAPE02029438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PH01; -.
DR STRING; 59463.ENSMLUP00000009934; -.
DR Ensembl; ENSMLUT00000010896.2; ENSMLUP00000009934.2; ENSMLUG00000010899.2.
DR eggNOG; ENOG502QRYF; Eukaryota.
DR GeneTree; ENSGT00950000182920; -.
DR HOGENOM; CLU_035133_0_1_1; -.
DR InParanoid; G1PH01; -.
DR OMA; QENCHEA; -.
DR TreeFam; TF328397; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042149; P:cellular response to glucose starvation; IEA:Ensembl.
DR GO; GO:1905691; P:lipid droplet disassembly; IEA:Ensembl.
DR GO; GO:0019915; P:lipid storage; IEA:Ensembl.
DR GO; GO:0015909; P:long-chain fatty acid transport; IEA:Ensembl.
DR Gene3D; 1.20.120.340; Flagellar protein FliS; 1.
DR Gene3D; 3.30.720.170; Perilipin, alpha-beta domain; 1.
DR InterPro; IPR004279; Perilipin.
DR PANTHER; PTHR14024; PERILIPIN; 1.
DR PANTHER; PTHR14024:SF25; PERILIPIN-2; 1.
DR Pfam; PF03036; Perilipin; 1.
DR PIRSF; PIRSF036881; PAT; 1.
DR SUPFAM; SSF109775; Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT REGION 413..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 49354 MW; E5D38D04323A24DF CRC64;
MASVAVDPQP SVVTRVANLP LVSSTYDLVS SAYVTTKDQY PCLKSVCEMA EKGVKTITSV
AVMSAQPIIQ KLEPQIAVAN NYACMGLDRI EEKLPILNQP TKQVVANAKG AVTGAKDAVT
TTVTGAKDSV TSTITGVVDK TKEAVTGSVE KTKSVVNDSI NTVMGSRMMQ LVSSGVENAL
STSELLVDQY LPLTEEELEK EAKKVEGFET VQKPSYYIRL GSLSTKLRSR AYQQALGRVK
EAKQKSQETI SQLHSTVNLI EFARENVHSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES
HCAEHIESRT LAIARNLTQQ LQTTCSTLLS NVQGLPQNIQ DQASHVGVMA GDIYAVFRNA
SSFKEVSDGF LTSSKGQLQK MKESLDNVMD YLVNNTPLNW LVGPFHPQII ESQNAQRRTQ
PASRPSSLSP KHSDSVPVTS AWCSQPDDIF C
//
