ID G1PH82_MYOLU Unreviewed; 1552 AA.
AC G1PH82;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Rho guanine nucleotide exchange factor 11 {ECO:0000313|Ensembl:ENSMLUP00000010025.2};
GN Name=ARHGEF11 {ECO:0000313|Ensembl:ENSMLUP00000010025.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010025.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010025.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010025.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AAPE02034942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000010025; -.
DR Ensembl; ENSMLUT00000011000.2; ENSMLUP00000010025.2; ENSMLUG00000010956.2.
DR eggNOG; KOG3520; Eukaryota.
DR GeneTree; ENSGT00940000158350; -.
DR HOGENOM; CLU_003962_5_0_1; -.
DR InParanoid; G1PH82; -.
DR OMA; FICGERQ; -.
DR TreeFam; TF106495; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd08753; RGS_PDZRhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR037889; PDZRhoGEF_RGS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00315; RGS; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 45..109
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 351..412
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 773..962
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1004..1118
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 17..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1257..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..159
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..682
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1141
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 171167 MW; 6A81253A679AC3E6 CRC64;
SLICFYYSFS RLSSLSLGDS APERKSPSHH GQPDSSETTG LVQRCVIIQK DQHGFGFTVS
GDRIVLVQSV RPGGAAMKAG VKEGDRIIKV NGTMVANSSH LEVVKLIKSG AYVALTLLGS
SPSTVGVSGL QQDPDPAGAP QVAPVIPPPP PPPPLPPPQR ITGPTPLQDL EFQKHATQIL
RNMLRQEEKE LQHICEMYSR NPTSLLEEQI EAARRRVTQL QLKIQQETGG LVDILPLYSD
ISQRSSEGRL SLDSQDGDSG LDSGTERFPS LSESLINRNS VLSDPGLDSP RTSPVIMARV
AQHHRWQGSD APAAPTSDQG ADQSPKPLII GPEEDYDPGY FNNESDIIFQ DLEKLKSRPA
HLGVFLRYIF SQADPSPLLF YLCAEVYQQT NSKDSRSLGK DIWNIFLEKN APLRVKVPEA
LQAEIDLRLR SGEDLRCVLC EAQEAAMPEI QEQIQDYRSK RTLGLGSLYG ENDLLDLDGN
PLRERQVAEK QLAALGDILF KYEEDRSAPM DFALNTYMSH AGIRLREARS SSTAEKAPLS
APDKDKWLPF FPKTKKSSNP KKEKDALEDK KRNPILKYIG KPKSSSQSTF HIPLSPVEVK
PGNVRNIIQH FENNQQYDAP EPGMQRLSTG SFPEDLLESD SSRSEIRLGR SESLKGREEL
KRSRKTENVP RSRSDVDMDA AAEAARLHQS ASSSASSLST RSLENPTPPF TPKMGRRSIE
SPSLGFCTDV LLPHLLEDDL GQLSDLELEP DTQNWQHTVG KDVVAGLTQR EIDRQEVINE
LFVTEASHLR TLRVLDLIFY QRMKKENLMP REELARLFPN LPELIEIHNS WCEAMKKLRE
EGPIIKEISD LMLARFDGPA REELQQVAAQ FCSYQSIALE LIKTKQRKES RFQLFMQEAE
SHPQCRRLQL RDLIISEMQR LTKYPLLLES IIKHTEGGTS EHEKLCRARD QCREILKYVN
EAVKQTENRH RLEGYQETDT TSLERASNPL AADLRKSLDL TTRKMIHEGP LTWRISKDKT
LDLHVLLLED LLVLLLKQDE KLLLKCHSKT AMGSSDSKQT FSPVLKLNAV LVRSVATDKR
AFFIICTSEL GPPQIYELVA LTSSDKNTWM ELLEEAVRNA TRHPGAAPTP VLPPPPGPQE
SAHQSPRSSR VGLDDSEVFQ REPEPEVLPG GTGPQPGVTG KHSVLLEDLK HEGSMEATEL
GALPHPSASL DGENRGGRTR DPIVLPLPGP LFMEGLADAA LEDVEILRHL ILRGQLPSHP
REPQAAGEPE DDLTPTPSVV SITSHPWDPG SPGRAPTEGE GENTQLPGPE GGQPEQEDVA
LCSLEHLPPR TRNSGIWEPP ELDRSPEEEA SSTEAAGSYK VVRKAEVAGS KAVPALPEGG
QSEAEPPEVE GGAKATGNCF YVSMPAGPPD SSTDLSQPNG LPAWRTEPQP RGGNGEPRRP
SCSPPSLAVK DMGIIFQTIE QLTLKLNRLK DMELAYRELL RSLGGESSGG TTPVGSFHTE
AAKWADCSLS PPVKDPPPSA SWDSHELGPC PEDSTRSPRE DSVADAATPP GL
//