ID G1PHC1_MYOLU Unreviewed; 356 AA.
AC G1PHC1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Solute carrier family 35 member B1 {ECO:0000256|ARBA:ARBA00040754};
GN Name=SLC35B1 {ECO:0000313|Ensembl:ENSMLUP00000010066.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010066.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010066.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010066.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000256|ARBA:ARBA00010694}.
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DR EMBL; AAPE02037706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006099011.1; XM_006098949.2.
DR AlphaFoldDB; G1PHC1; -.
DR STRING; 59463.ENSMLUP00000010066; -.
DR Ensembl; ENSMLUT00000011046.2; ENSMLUP00000010066.2; ENSMLUG00000011047.2.
DR GeneID; 102439040; -.
DR KEGG; mlf:102439040; -.
DR CTD; 10237; -.
DR eggNOG; KOG1580; Eukaryota.
DR GeneTree; ENSGT00940000157900; -.
DR HOGENOM; CLU_036019_1_0_1; -.
DR InParanoid; G1PHC1; -.
DR OMA; CGAIGQV; -.
DR OrthoDB; 614761at2759; -.
DR TreeFam; TF105967; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:Ensembl.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR013657; SCL35B1-4/HUT1.
DR PANTHER; PTHR10778; SOLUTE CARRIER FAMILY 35 MEMBER B; 1.
DR PANTHER; PTHR10778:SF10; SOLUTE CARRIER FAMILY 35 MEMBER B1; 1.
DR Pfam; PF08449; UAA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 356 AA; 39182 MW; 7648CD45AF1B13D2 CRC64;
MRPLSPVGDV RLELSPPLPL PAVSGSPVGS PGRLMAASNS LVPDRLRLPL CFLGVFVCYF
YYGILQEKIT RGKYGEGAKQ ETFTFALTLV FIQCVINAVF AKILIQFFDT ARVDRTRSWL
YAACSISYLG AMVSSNSALQ FVNYPTQVLG KSCKPIPVML LGVTLLKKKY PMAKYLCVLL
IVAGVALFMY KPKKVVGMEE HTIGYGELLL LLSLTLDGLT GVSQDHMRAH YQTGSNHMML
NINLWSTLLL GAAILFTGEL WEFLSFADRY PAIIYNILLF GLTSALGQSF IFMTVVYFGP
LTCSIITTTR KFFTILASVI LFANPISSMQ WVGTVLVFLG LGLDAKFGKG AKKTSH
//
