ID G1PIJ2_MYOLU Unreviewed; 405 AA.
AC G1PIJ2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Kelch domain containing 2 {ECO:0000313|Ensembl:ENSMLUP00000010524.2};
GN Name=KLHDC2 {ECO:0000313|Ensembl:ENSMLUP00000010524.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010524.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010524.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010524.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AAPE02015704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006087873.1; XM_006087811.2.
DR AlphaFoldDB; G1PIJ2; -.
DR STRING; 59463.ENSMLUP00000010524; -.
DR Ensembl; ENSMLUT00000011552.2; ENSMLUP00000010524.2; ENSMLUG00000011551.2.
DR GeneID; 102417808; -.
DR KEGG; mlf:102417808; -.
DR CTD; 23588; -.
DR eggNOG; KOG0379; Eukaryota.
DR GeneTree; ENSGT00940000157150; -.
DR HOGENOM; CLU_042804_0_0_1; -.
DR InParanoid; G1PIJ2; -.
DR OMA; MGKLLQF; -.
DR OrthoDB; 2906516at2759; -.
DR TreeFam; TF314081; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0140627; P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; IEA:Ensembl.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR PANTHER; PTHR46228; KELCH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46228:SF3; KELCH DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF13418; Kelch_4; 2.
DR Pfam; PF13854; Kelch_5; 1.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 405 AA; 45972 MW; 3467FCA66B511CD1 CRC64;
MADGHDDPRD DLPGPAYESC EAAELACPAE RSGHVAVGDG RHMFVWGGYK SNQVRGLYDF
YLPREELWIY NMETGRWKKM NTEGDVPPSM SGSCAVCVDR MLYLFGGHHS RGNTNKFYML
DLRSTDRVLQ WERIDCQGIP PSSKDKLGVW VYKNRLIFFG GYGYLPEDKV LGTFEFDETS
FWNSSHPRGW NDHVHILDTE TFIWSQPLTT GKAPSPRAAH ACATVGNKGF VFGGRYRDAR
MNDLHYLNLD TWEWNELIPQ GMCPVGRSWH SLTPVSSDHL FLFGGFTTDK QPLSDAWTYC
ISKNEWLQFN HPYTDKPRLW HTACASDEGE VIVFGGCANN LLVHHRAAHS NEVLIFSVQP
KSLVRLSLEA VICFKEMLAN SWNCLPKHLL HSVHQRFGSN NTSGS
//
