ID G1PIX1_MYOLU Unreviewed; 361 AA.
AC G1PIX1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=NADPH oxidase organizer 1 {ECO:0000313|Ensembl:ENSMLUP00000010676.2};
GN Name=NOXO1 {ECO:0000313|Ensembl:ENSMLUP00000010676.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010676.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010676.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010676.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02041703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006100958.1; XM_006100896.2.
DR AlphaFoldDB; G1PIX1; -.
DR STRING; 59463.ENSMLUP00000010676; -.
DR Ensembl; ENSMLUT00000011720.2; ENSMLUP00000010676.2; ENSMLUG00000011725.2.
DR eggNOG; ENOG502QW5I; Eukaryota.
DR GeneTree; ENSGT00940000158812; -.
DR HOGENOM; CLU_030529_2_0_1; -.
DR InParanoid; G1PIX1; -.
DR OMA; QQMAWFP; -.
DR OrthoDB; 26167at2759; -.
DR TreeFam; TF329347; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:Ensembl.
DR GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0006801; P:superoxide metabolic process; IEA:Ensembl.
DR CDD; cd12024; SH3_NoxO1_2; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035758; NoxO1_SH3_2.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF10; NADPH OXIDASE ORGANIZER 1; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..127
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 158..220
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 232..291
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 297..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 39353 MW; 6E2A6BA47D7D196E CRC64;
MVGPRHPVSV RAAALVQIEK LQMFAFSVCW SDDSNTLVRR SWDEFKRLHK ILKETFPVEA
GLLRRSDRVL PKLPDASTSL LARGGRKGRG LARLQLLEAY SQALLEAEQV SRGPLLTAFF
EPQLQDLEPS LPLGSLVILP VLEEPPPRPV GSLAIGSLEA LRLHCLQPFS TQDTRGQPFH
AQAQEALDVL LRHPSGWWLV ANEDQQTAWF PAPYLEEVAL GQGQDGRQPL RSSGSQFCAS
QAYEGSRADE LSVPAGARVR VLEMSDRGWW LCRFGGRTGL LPSVLLQADG LGTLLNGPGL
PSGAEGGENR AGEAQSSPKS PQVMTLPPTV PARPLLSAIQ NRCCTITRRA LGRDPRSQGH
P
//
