ID G1PJ55_MYOLU Unreviewed; 123 AA.
AC G1PJ55;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=WAP four-disulfide core domain protein 5 {ECO:0000256|ARBA:ARBA00017105};
GN Name=WFDC5 {ECO:0000313|Ensembl:ENSMLUP00000010770.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010770.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010770.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010770.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative acid-stable proteinase inhibitor.
CC {ECO:0000256|ARBA:ARBA00003209}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02023345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PJ55; -.
DR STRING; 59463.ENSMLUP00000010770; -.
DR Ensembl; ENSMLUT00000011822.2; ENSMLUP00000010770.2; ENSMLUG00000011821.2.
DR eggNOG; ENOG502S99V; Eukaryota.
DR GeneTree; ENSGT00730000111369; -.
DR HOGENOM; CLU_105901_2_0_1; -.
DR InParanoid; G1PJ55; -.
DR OMA; KRCCPGA; -.
DR TreeFam; TF338375; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 4.10.75.10; Elafin-like; 2.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR PANTHER; PTHR19441:SF39; WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 5; 1.
DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1.
DR Pfam; PF00095; WAP; 2.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 2.
DR SUPFAM; SSF57256; Elafin-like; 2.
DR PROSITE; PS51390; WAP; 2.
PE 4: Predicted;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 28..74
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 75..122
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
SQ SEQUENCE 123 AA; 13651 MW; 18D1F22866DE7C6E CRC64;
ECRAGESRVS PYSRTLVCLQ PQYLGGSLPE RHGGCPPDDG PCLHSVPDQC VDDSQCPSKM
KCCHRSCFRQ CVRRVTVKQG TCPEDRMHCL SPIQHLCHKD TDCRGSSRCC LGACGRDCRN
PVR
//
