ID G1PJE7_MYOLU Unreviewed; 449 AA.
AC G1PJE7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=T-box transcription factor 19 {ECO:0000313|Ensembl:ENSMLUP00000010871.2};
GN Name=TBX19 {ECO:0000313|Ensembl:ENSMLUP00000010871.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010871.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010871.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010871.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR EMBL; AAPE02056715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02056716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02056717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02056718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02056719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PJE7; -.
DR STRING; 59463.ENSMLUP00000010871; -.
DR Ensembl; ENSMLUT00000011933.2; ENSMLUP00000010871.2; ENSMLUG00000011933.2.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000160000; -.
DR HOGENOM; CLU_038303_0_0_1; -.
DR InParanoid; G1PJE7; -.
DR OMA; SAYVHRN; -.
DR TreeFam; TF106341; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20201; T-box_TBX19-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF114; T-BOX TRANSCRIPTION FACTOR TBX19; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 45..218
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
SQ SEQUENCE 449 AA; 48360 MW; 9B9DFF628B19F4A9 CRC64;
VAMSELGAQK TGDGTVSRLL DVVESELQAG REKGDPTEKQ LRITLEDAPL WQRFKEVTNE
MIVTKNGRRM FPVLKISVTG LDPNAMYSLL LDFVPTDSHR WKYVNGEWVP AGKPEVASHS
CVYIHPDSPN FGAHWMKAPI SFSKVKLTNK LSGGGQIMLN SLHKYEPQVH IVRVGGAHRM
VMNCSFPETQ FIAVTAYQNE EITALKIKYN PFAKAFLDAK ERNHLKDIPE AISESQHLAC
PHLGGWIFSN PGVCSAGNAN FQYAPPLPLS APHTHHGCER YGLRGHRPAP YPSYMHRNHS
FSRNMISTGQ GDLWLPALRT GWAGFSAESG PVCQSRSKAT ARGPLSSPTA SQYPLPCLWT
ISNGGGGPCR AGPRTGTPGP PGDIFLLGNP AVTSPLSTQA PTSAAVEVLG EPSLTSIAVS
TWTAVASHPF AGWGGSGGGG RHSPSSLDS
//
