ID G1PJV6_MYOLU Unreviewed; 679 AA.
AC G1PJV6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Neurofilament heavy {ECO:0000313|Ensembl:ENSMLUP00000011048.2};
GN Name=NEFH {ECO:0000313|Ensembl:ENSMLUP00000011048.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011048.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011048.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011048.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AAPE02038436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PJV6; -.
DR STRING; 59463.ENSMLUP00000011048; -.
DR Ensembl; ENSMLUT00000012125.2; ENSMLUP00000011048.2; ENSMLUG00000012127.2.
DR eggNOG; ENOG502QYDU; Eukaryota.
DR GeneTree; ENSGT00940000161893; -.
DR HOGENOM; CLU_012560_7_2_1; -.
DR InParanoid; G1PJV6; -.
DR OMA; FHSWTRT; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0097418; C:neurofibrillary tangle; IEA:Ensembl.
DR GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
DR GO; GO:0061564; P:axon development; IEA:Ensembl.
DR GO; GO:0033693; P:neurofilament bundle assembly; IEA:Ensembl.
DR GO; GO:1902513; P:regulation of organelle transport along microtubule; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR010790; DUF1388.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF07142; DUF1388; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 1..202
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 247..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..173
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 251..286
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 74987 MW; 9A9864EB888FEC52 CRC64;
ARAELQKKVQ SLQEECGYLR RHHQEEVAEL LSQLQGCGAA QAQAQADARD ALKCDVTSAL
REIRAQLEGH TVQSTLQSEE WFRVRLDRLS EAAKVNTDAM RSAQEEISEY RRQLQARTTE
LEALKSTKDS LERQRSELED RHQTDIASYQ DAIQQLDAEL RNTKWEMAAQ LREYQDLLNV
KMALDIEIAA YRKLLEGEEC RIGFGPSPFS LPEGLPKMPS TATHIKVKSE EKIRVVEKSE
KETVIVEEQT EEIQVTEEVT EEEEKEAKEE EGEEEERGEE EEAEGGEEAT KSPPAEEAAS
PEAEAKSPEK EEAKSPAKTP MKEEAKSPAE VKSPEQAKSP GKEEAKSPAK EEAKSPSEVK
SPEKEEAKSP SEAKSPEKAK SPGKEEAKSP PEVKSPEKAG SPTKEEAKSP EKAKTLDVKS
PGAKTPVKEE VRSPADIKSP VKPKSPGKEE VKSLEKVKSP VKEEAKAPEK VSKKEEAKSP
MKEDEKPQEV KVKEPPKKVE EEKAPATPKT EKDSKKDEVP KKEAPKPEVQ EKPKESAAEA
KKEEAEGKKK AATPEKEAPA KEKEEAKAKE KTEVDKKEPG DAKAKGPSKA AEKGPEKPKK
EETSAAPEKK DAKEEKATEA KKPEEKPKPE ARAKEEPSKE APAPSKAKTE KAEKSSSTDH
KDSRPPEKAT GDKAAQGEK
//
