ID G1PK07_MYOLU Unreviewed; 1785 AA.
AC G1PK07;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Cullin 7 {ECO:0000313|Ensembl:ENSMLUP00000011106.2};
GN Name=CUL7 {ECO:0000313|Ensembl:ENSMLUP00000011106.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011106.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011106.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011106.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; AAPE02041020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02041021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000011106; -.
DR Ensembl; ENSMLUT00000012190.2; ENSMLUP00000011106.2; ENSMLUG00000012163.2.
DR eggNOG; ENOG502RDJD; Eukaryota.
DR GeneTree; ENSGT00940000153954; -.
DR HOGENOM; CLU_001067_0_0_1; -.
DR InParanoid; G1PK07; -.
DR OMA; RCWPVAS; -.
DR TreeFam; TF101154; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:1990393; C:3M complex; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0031467; C:Cul7-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
DR GO; GO:0001890; P:placenta development; IEA:Ensembl.
DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0007088; P:regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021097; CPH_domain.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22771:SF3; CULLIN-7; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF11515; Cul7; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
DR PROSITE; PS51284; DOC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 899..1078
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1299..1593
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1434..1448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1785 AA; 199976 MW; 2ED716D3AD0356C0 CRC64;
MSRGSGQVAA PRAGRWHRGW APPRPAPGAA DLRAGSGDST AGHAPSRLPI STPFGGPSAS
MVGELRYREF RVPLGPGLHA YPDELIRQRW GHNGHPEYQI RWLVLRRGED GEGGSSQVDC
KAEHILLWMS SDEIYANCHK MLGEDGQVIW PSQETAGEAG ALDKSVLEEM ETDVKSLIQR
ALRQLEECVG TMPPAPLLHT VHVLSAYASI EPLTGVFKDP RVLDLLMHML SSPDYQIRWS
AGRMIQALAS HDAGEEQCGE EGRAGERLGR LRALQEPLTS SIHKLLRTRT QILLSLSQQE
AIEKHLDFDS RCALLALFAQ ATLSEHPMSF EGIQLPQVPG RLLFSLVKRY LHVASLLDQL
NDSAAEPGAQ NSSAPEELSR ERGRLELEFS MAMGTLISEL VQAMRWDWAS SRQGPLARSS
CSIFQPQLAD AGLALPPTQA QSSLRRSRRF RPRSEFASGN TYALYVRDTL QPGMRVRMLD
DYEEISAGDE GKFQQSNNGV PPVQVLWEST GRTYWVHWHM LEILGFEEDI EDMAEADEYR
GAVGSGAQGV ALPSWRWKPM AELYAVPYVL PEDEDTEDSE HLTQAEWWEL LFFIKKLDGP
DHQEVLQILQ ENLDGEVLDD EILAELAVPM ELAQDLLLAL PERLDDSALR DLLSCRVYRK
YAPEALAGQP AYPSLLDAQA QPQESADAAR VEAEEPPTQQ CPRSPLRHLV EGYGPAGKIV
LDLEQALSSE GTQESEVKSL LLLLRQQPQP FLVLMQSLDT PAANRALHLA VLRILMRLVD
FPEALLLPWH EAMDACMACL RSPDADREVL QELIFFLHRL ASASRDYAVV LNQLGARDAV
SKALEKHLGK LDLAQELRDM VFKCEKHAHL YRKLTTNILG GCIQMVLGQI EDYRRTHRPI
NIPFFDVFLR YLCQGSSVEV KEDKCWEKVE VSSNPHRASR LTDRNPKTYW ESNGSTGSHS
ITVHMRQGVL IRQLTLLVAG EDSSYMPARV VVFGGDSASS LNTELNSVNV MPSARRVVLL
ENLNRFWPVI QIRIKRCQQG GIDTRIRGLE VLGPKPTFWP VFREQLCRHT RLFYMVRAQA
WSQDIAEDRK RLLHLSSRLN GALRQEQNFA DRFLPDDEAA QALGKTCWEA LVSPLVQNIT
CPDEDGVSPL GWLLDQYLQC REAAHNPQSR AAAFSSRVRR LTHLLVHVEP CEVPAAAGAR
RPNGRNRSHD WGSLATPGLP SSIVKNLTRC WQAAVEEQVN SFLTSHWRDD DFVPRYCEHF
NNLQKSSSEL FGPRAAFLLA LQNGCAGALL KLPFLQAAHV SEQFARHIDQ RIQGSRIGGA
RGMEMLAHLQ RCLETVLIFS GLEIATTFEH YYQHYMADRL LSLGSSWLEG AVLEQIGPCF
PHRLPQQMLR TLSTSEELQR QFHVYQLQRL DQELLKLEDT EKKIQVGASQ ETSGKEHVGE
RQEEAEEAGA AAAAEVTEEE EEENEDLFYE GAMPEVSVLV LSPRCWPTAS ICHTLNPKTC
LPSYLRGTLN QYSNFYNKSQ SYPVLEQGPQ RRLQWTWLGR AEVQFGDQTL HVSTVQMWLL
LYLNDLKAVS VENLRALSGL PADTLNQAIG LLTSSRGPLD LHEQKDIPGG VLKIRDDSEE
PRPRRGNVWL IPPQTYLKAE DEEGRNLEKR RNLLNCLIVR ILKAHGDEGL HVGQLVYLVL
EAWQKGPCPP RALVSGLGRG SACSSTDVLS CILHLLGKGT VRRRDDRPQM LSYAVPVTVM
EPHTESLNPG SSGPNPPLTF HTLQIRSRGV PYASCTATQS FSTFR
//
