ID G1PK83_MYOLU Unreviewed; 1024 AA.
AC G1PK83;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Family with sequence similarity 13 member A {ECO:0000313|Ensembl:ENSMLUP00000011193.2};
GN Name=FAM13A {ECO:0000313|Ensembl:ENSMLUP00000011193.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011193.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011193.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011193.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAM13 family.
CC {ECO:0000256|ARBA:ARBA00007549}.
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DR EMBL; AAPE02007756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PK83; -.
DR STRING; 59463.ENSMLUP00000011193; -.
DR Ensembl; ENSMLUT00000012292.2; ENSMLUP00000011193.2; ENSMLUG00000012281.2.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00950000183033; -.
DR HOGENOM; CLU_012606_1_0_1; -.
DR InParanoid; G1PK83; -.
DR OMA; ETHYCLL; -.
DR TreeFam; TF328895; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04393; RhoGAP_FAM13A1a; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR039102; FAM13.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15904; FAM13; 1.
DR PANTHER; PTHR15904:SF18; PROTEIN FAM13A; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 44..232
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 314..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 949..976
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 326..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 116602 MW; 19D6314B7BEE08FA CRC64;
MFSNTYILIQ QSKATVRLKE DMKKIVAVPL SEQKNSTYKK LFGVSLQDLQ QQGLTVNGIP
AIVGNIVEYL TKNGLTQEGL FRVNGNMKVV EQLRLKFESG VPVELREDGD VCAAASLLKL
FLRELPESVI PAALHPRFLQ LFQDDTNDAQ ENSLRALIKE LPDTHYCLLK YLCQFLTKVA
KHHVQNRMNV HNLATVFGPN CFHVPPGLEC MKEQDLCNKI MATILENYNT LFEVEHTGND
NQSYENPTKL IIVKEASYKN STPILLTKDL ERDVQKPSPK TKIPKSKSEG SLQVYRVPQP
ERCDGAAQVS LRLSRRKPGW GDMNSAEDTS GATLVSSSQE DERPLSPFYL SARVSQVSSV
STTGELLERT IRSAVEQHLF DVSSSGAQIS EDSESGTSLA PSTASARQRR RQSKEQDEVR
RGRDMGLINK ENIPSGLSNL DDCILNAQEV ESLHENTSGY IGERSKPKRQ KPSSKLSDLN
ENQDCLVNME SLNSTPSHES ARTDHIELMS DDRKENEKDS GHSQHFESPT MKIQEHPSIP
DTKLQRTPDA DTPQESFVLE VPRLDLTALC EEKSWADPMP PLSSWQQENG DSDDAPLSPP
AGHLIRQLLD EDSDPMISPR FYSYGQSRQY LDDTEVPPSP PNSHSFMRQR SCSLGSYDDE
HEDLTPAQLT RRIQSLKKKI RKFEDRFEEE RKYRPSHSDK AANPEVLKWT NDLAKFRKQL
KESKLKISEE DLTPRLRQRS NTLPRSFGSQ LEKEDEKKQE VVDKAIKPNV EATLDSIQRK
LQEKRAESSR PEDIKDMTKD QIANEKVALQ KALLHYESIH GRPVTKNERQ VMKPLYDRYR
LVKQILSRAN TMPIMGSPSS KRRSPLLQPI IEGETAFFFK ESKEEEEGSE DDSNTKPDFR
VTLKTEFSAH CFLDQLEDGA DGFISPMDDK MPSKCSQDSG LSNLHAASMP ELLEHLQEMR
EEKKRIRKKL REFEDNFFRQ NGRNVQKEDR TPMAEEYSEY KHIKAKLRLL EVLISKRDAD
SKSM
//
