ID G1PKC0_MYOLU Unreviewed; 544 AA.
AC G1PKC0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Intercellular adhesion molecule 3 {ECO:0000313|Ensembl:ENSMLUP00000011235.2};
GN Name=ICAM3 {ECO:0000313|Ensembl:ENSMLUP00000011235.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011235.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011235.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011235.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM family.
CC {ECO:0000256|ARBA:ARBA00005925}.
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DR EMBL; AAPE02048874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PKC0; -.
DR STRING; 59463.ENSMLUP00000011235; -.
DR Ensembl; ENSMLUT00000012340.2; ENSMLUP00000011235.2; ENSMLUG00000012338.2.
DR eggNOG; ENOG502RZRA; Eukaryota.
DR GeneTree; ENSGT00940000159005; -.
DR HOGENOM; CLU_036160_1_1_1; -.
DR InParanoid; G1PKC0; -.
DR OMA; MHILQCQ; -.
DR TreeFam; TF333745; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR003988; ICAM.
DR InterPro; IPR048679; ICAM1_3_5_D2.
DR InterPro; IPR013768; ICAM_N.
DR InterPro; IPR047012; ICAM_VCAM.
DR InterPro; IPR003987; ICAM_VCAM_N.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR PANTHER; PTHR13771:SF17; INTERCELLULAR ADHESION MOLECULE 3; 1.
DR Pfam; PF21146; ICAM1_3_5_D2; 1.
DR Pfam; PF03921; ICAM_N; 1.
DR PRINTS; PR01473; ICAM.
DR PRINTS; PR01472; ICAMVCAM1.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..544
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417209"
FT TRANSMEM 487..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..120
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 321..397
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 408..476
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
SQ SEQUENCE 544 AA; 58436 MW; E34CA95CB872BFD5 CRC64;
LATMVPLGPL PRACWTLLIS LFLVCCLLLA PGAQGQAFRL RVEPQNPVVP AGGSLLVNCS
TDCPQPELIS LETSLFKEEA GEGLGWKAYR LSSVTSDSEI FCSGICNGSQ MSDSSDITVY
QFPERVELAP LPPNPVGKNL TLRCRVAGHP RAQLSVLLLG AGVLSQQLAV GGVTTTVLAS
RNDHGANFSC RWELDLRSQG LGLFQNSSVP RQLRTFVLPV TPPRLLVPRF LEVGTSQAVT
CTLDGLFPAS EAQVHLALGG QMLNATVESN GDKLTARATA TASAELEGAQ EIVCNVTLGG
ESQETRENLT IYSFWGPVMN LSQPTVRQGT IVNVTCAAGA RVQVTLDGVP AAAPGQPALL
QLNASERDDR RSFFCSAALE VDGVVLHKNR SVQLRVLYGP KIDPARCPQH LMWKEKTTQI
LQCQAQGNPD PQLQCFHEGS MAQVPIGIPF RVRLNYSGTY NCRAASSQGT HTVTVVMKVQ
ERNPVTITIV IAVLTILGFV AAIPASIYVF GVHKRRDIYH VNQGNAEFPL TSKTAEEPLG
EPPS
//