ID G1PKG0_MYOLU Unreviewed; 926 AA.
AC G1PKG0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Protocadherin 10 {ECO:0000313|Ensembl:ENSMLUP00000011283.2};
GN Name=PCDH10 {ECO:0000313|Ensembl:ENSMLUP00000011283.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011283.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011283.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011283.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02001378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PKG0; -.
DR STRING; 59463.ENSMLUP00000011283; -.
DR Ensembl; ENSMLUT00000012391.2; ENSMLUP00000011283.2; ENSMLUG00000012385.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000158277; -.
DR HOGENOM; CLU_006480_1_2_1; -.
DR InParanoid; G1PKG0; -.
DR OMA; FPLEMIV; -.
DR TreeFam; TF352008; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF0; PROTOCADHERIN-10; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 659..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..103
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 104..212
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 213..418
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 414..519
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 535..625
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 631..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 101186 MW; 5AB5550958248C1B CRC64;
LHYTVQEEQE HGTFVGNIAE DLGLDITKLS ARRFQTVPNS RTPYLDLNLE TGVLYVNEKI
DREQICKQSP SCVLHLEVFL ENPLELFRVE IEVLDINDNP PSFPEPDLTV EISESATPGT
RFPLESAFDP DVGTNSLRDY EITPNSYFSL DVQTQGDGNR FAELVLEKPL DREQQAVHRY
VLTAVDGGGG QRTGTALLTI RVLDSNDNVP AFDQPVYTVS LPENSPPGTL VIQLNATDPD
EGQNGEVVYS FSSHISPRAR ELFGLSSRTG RLEVSSLDYE ESPVYQVYVQ AKDLGPNAVP
AHCKGAGAGC LDANDKRAGR SASAPAPGTV VALFSVTDRD SEENGQVQCE LLGDVPFRLK
SSFKNYYTIV TEAPLDREAD SYTLTVVGPG GEPSLSTSKS IQVQVSDVND KRAFPPSRVY
DVTENNVPGA YIYAVSATDR DEGANAQLAY SILECQIQGM SVFTYVSINS ENGYLYALRS
FDYEQLFHVE ARDAGSSGAG GQRTVNILIV DQNDNAPAIV APLPGRNGTP AREVLPRSAE
PGYLLTRVAA VDADDGENAR LTYSIVRGNE MNLFRMDWRT GELRTARRVP AKRDPQRPYE
LVIEVRDHGQ PPLSSTATLV VQLVDGAVEP QGGGGGGGGG SGEHQRPNRS GGGETSLDLT
LILIIALGSV SFIFLLAMIV LAVRCQKEKK LNIYTCLASD CCLCCCCGSG GSTCCGRQAR
ARKKKLSKSD IMLVQSSNVT SNPAQVPVEE SGGFGSHHHN QNYCYQALIN CLNSNYTPKH
FFRPLKERLQ SITRLTLLET IVYEPQTKHQ RAELSYLVDR PRRVNSSAFQ EADIVSSKDS
GHGDSEQGDS DHDATNRGHL VKVLSMSFSN RLFLRSEEIP SGMDLFSNCT EECKALGHSD
RCWMPSFVPS DGRQAADYRS NLHVPG
//
