ID G1PKS7_MYOLU Unreviewed; 1388 AA.
AC G1PKS7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Dispatched RND transporter family member 3 {ECO:0000313|Ensembl:ENSMLUP00000011426.2};
GN Name=DISP3 {ECO:0000313|Ensembl:ENSMLUP00000011426.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011426.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011426.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011426.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAPE02047934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02047935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006103781.1; XM_006103719.2.
DR STRING; 59463.ENSMLUP00000011426; -.
DR Ensembl; ENSMLUT00000012557.2; ENSMLUP00000011426.2; ENSMLUG00000012547.2.
DR GeneID; 102435791; -.
DR KEGG; mlf:102435791; -.
DR CTD; 57540; -.
DR eggNOG; KOG3664; Eukaryota.
DR GeneTree; ENSGT00940000157931; -.
DR HOGENOM; CLU_007038_0_0_1; -.
DR InParanoid; G1PKS7; -.
DR OMA; RWDYSRT; -.
DR OrthoDB; 2909370at2759; -.
DR TreeFam; TF331579; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0045834; P:positive regulation of lipid metabolic process; IEA:Ensembl.
DR GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IEA:Ensembl.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR042480; DISP3.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR46687; PROTEIN DISPATCHED HOMOLOG 3; 1.
DR PANTHER; PTHR46687:SF1; PROTEIN DISPATCHED HOMOLOG 3; 1.
DR Pfam; PF03176; MMPL; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 74..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1179..1197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1203..1224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1285..1311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1317..1340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1352..1378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 506..611
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1388 AA; 152460 MW; 0E0067E5583C31BE CRC64;
MDSEDDPLLQ DVWLEEEQED EEATGEAFRR AQKPGPQAGA EGQCCWRGWT LPSRPPASGF
WSTLGWAFTN PCCAGLVLFL GCSIPMALSA FMFLYYPPLD IDISYNAFEI RNHEASQRFD
ALALALKSQF GSWGRNRRDL ADFTSETLQR LISEQLQQLH LGNRSQRVAR APRAVPAAPG
CGPGPGRDSA TARKPAANQS GRLRDASTLA DLAANQSEAP LTQGLDRNGR GQLGTPPTLA
NQSRARRGAS RWDYSRSYVS TNTQTHAHWR IELIFLARGD AERNIFTSER LVTIHEIERK
IMDHPGFREF CWKPHEVLKD LPLGSYSYCS PPSSLMTYFF PTERGGKIYY DGMGQDLADI
RGSLELAMTH PEFYWYVDEG LSAENLKSSL LRSEILFGAP LPNYYSVDDR WEEQRAKFQS
FVVTYVAMLA KQSTSKVQVL YGGTDLFDYE VRRTFNNDML LAFISSSCIA ALVYILTSCS
VFLSFFGIAS IGLSCLVALF LYHVVFGVQY LGILNGVAAF VIVGIGVDDV FVFINTYRQA
THLEDPQLRM IHTIQTAGKA TFFTSLTTAA AYAANVFSQI PAVHDFGLFM SLIVSCCWLA
VLFTMPAALG IWSLYMAPLE GACQTSCHQK CGRKSSLHFP GDVFATPERA GGGPAQGPLP
YLDDDIPLLN VEEEPVSLEL GDVSLVSVPP TGLQPVPDRG SRGQLIAQLQ ELLHHWVLWS
AVKSRWVIVG LFVSILILSL VFASRLRPAS RAPLLFRPDT NIQVLLDLKY NLSAEGISCI
TCSGLFQEKP HSLQNNIRTS LEKKKRGSGV LWASRPEVTP QDSPGTVYVS KVKSKGRPAV
YRFSLNASLP APWQIVSPGD GEVPSFQVYR APFGNFTRKL TACMSTVGQL QAASPARRWM
VTTLACDAKR GWKFDFSFYV AAQEQQHTRK LYFAQYHRPP FHGRVCATPP GCLLSSSPDG
PTKGFFYVPS EKGPRARLSA TFGFNPCVNT GCGKPAVRPL VDTGAMVFVV FGIVGINRTR
QVDNHVIGDP GSVIYDSGFD LFKEIGHLCR LCKAIAGNLE LVKPGGAQCL PSGYSISAFL
QMLHPECKEL PEPNLLPGQL SHGAVGVKEG RVQWISMAFE STTYKGKSSF QTYSDYLRWE
SFLQQQLQTF PEGSALRRGF QTCEHWKQIF MEIIGVQSAL YGLALSLLIC VAAVAVFTTH
VLLLLPVLLS ILGIVCLVVT IMYWSGWEMG AVEAISLSIL VGSSVDYCVH LVEGYLLAGE
NLPPHQAEDA HSQRQWRTLE AVRHVGVAIV SSALTTVIAT VPLFFCIIAP FAKFGKIVAL
NTGVSILYTL TVSTALLGIM APGSFTRTRT SFLKALGAVL LAGALGLGAC LLLLWSGYKI
PLPNGTSL
//
