ID G1PMR8_MYOLU Unreviewed; 868 AA.
AC G1PMR8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Transforming growth factor beta receptor associated protein 1 {ECO:0000313|Ensembl:ENSMLUP00000012204.2};
GN Name=TGFBRAP1 {ECO:0000313|Ensembl:ENSMLUP00000012204.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012204.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000012204.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000012204.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02036300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006098414.1; XM_006098352.2.
DR AlphaFoldDB; G1PMR8; -.
DR STRING; 59463.ENSMLUP00000012204; -.
DR Ensembl; ENSMLUT00000013415.2; ENSMLUP00000012204.2; ENSMLUG00000013409.2.
DR GeneID; 102442908; -.
DR KEGG; mlf:102442908; -.
DR CTD; 9392; -.
DR eggNOG; KOG2063; Eukaryota.
DR GeneTree; ENSGT00530000063596; -.
DR HOGENOM; CLU_004190_3_0_1; -.
DR InParanoid; G1PMR8; -.
DR OMA; VLKEIQC; -.
DR OrthoDB; 198927at2759; -.
DR TreeFam; TF328650; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0033263; C:CORVET complex; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:Ensembl.
DR GO; GO:0034058; P:endosomal vesicle fusion; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR InterPro; IPR019452; VPS39/TGF_beta_rcpt-assoc_1.
DR InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR PANTHER; PTHR12894; CNH DOMAIN CONTAINING; 1.
DR PANTHER; PTHR12894:SF27; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF10366; Vps39_1; 1.
DR Pfam; PF10367; Vps39_2; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50219; CNH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 24..297
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
SQ SEQUENCE 868 AA; 97276 MW; 040B3F74DE19163C CRC64;
MMSTKAFTLV SAVERELLMG DKERVNIECV ECCGKNLYVG TNDCSIYHFL LEEQSLPAGT
ATFTATKQLH RHLGLRKPVC ELRAASALHR LLVLCDYSIT LVHMLSLEPV PSGARIKGAV
ALALNENPVS GDPFCVEVCI ISVKRRTIQV FMVYEDRVQI VREVSTPEQP LAVAVDGHFL
CLALTTQYII LNYSTGAAQD LFPYCSEEKR PIVKRIGRQE FLLAGPGGLG MFATVAGISQ
RAPVHWSENV IGAAVCFPYV LALDDAFITV HSMLDQQQKQ TLPFKEGHIL QDFEGRVIVA
TSKGVYILVP LPLEKQIQDL LASHRVEEAL VLAKGARRNI PKEKFQGMYR RILQQAGFIH
FAQLQFLEAK ELFRSGQLDV RELISLCPFL LPTSSSFTRS HPPLHEYADL NQLTQGDQEK
AAKCKRFLMT YLEEVRSSEV VHSYKEDVDT ALLKLYAEAG HASLLDLLVT ENACLLADSA
AWLEKHKRYF ALGLLYHHND QDAAAVQLWV NIVNGEIDDP TRADLYDYVV DFLTHSPDHA
LVWKHADWAL QKSEEVGVQV FTRRPLEEQQ DGFNPDDVLT RLKKYPNALV RYLEHLVMDR
NLQREEYHTR LALLYLDAVL QRTPGASGSG AEVTETQAKL RRLLQKSDLY RVHFLMERVR
DAGLPMERAI LHGKLEEHEQ ALRTLALELG DFPAAEDYCA WRSVGREPAY RRRLFHTLLA
LYLGPGPSPP ASASASASAE LAVAAVDLLN RHAAEFDAAQ VLQLLPGTWS VQLLCPFLTG
AVRDSTHTRR TAQVALGLAT SENLIYKHDQ MKLKRSSFRL SDKQLCQVCH SPFCEPVFVR
YPTGDLVHTH CAASRHTNPS APRPGART
//
