ID G1PP78_MYOLU Unreviewed; 171 AA.
AC G1PP78;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=T-cell surface glycoprotein CD3 delta chain {ECO:0000256|ARBA:ARBA00014256};
DE AltName: Full=T-cell receptor T3 delta chain {ECO:0000256|ARBA:ARBA00030628};
GN Name=CD3D {ECO:0000313|Ensembl:ENSMLUP00000012796.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012796.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000012796.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000012796.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR EMBL; AAPE02049440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006104370.1; XM_006104308.2.
DR AlphaFoldDB; G1PP78; -.
DR STRING; 59463.ENSMLUP00000012796; -.
DR Ensembl; ENSMLUT00000014070.2; ENSMLUP00000012796.2; ENSMLUG00000014067.2.
DR GeneID; 102436834; -.
DR KEGG; mlf:102436834; -.
DR CTD; 915; -.
DR eggNOG; ENOG502S4XC; Eukaryota.
DR GeneTree; ENSGT00940000153312; -.
DR HOGENOM; CLU_115449_0_0_1; -.
DR InParanoid; G1PP78; -.
DR OMA; YQPLRDH; -.
DR OrthoDB; 4266454at2759; -.
DR TreeFam; TF335892; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0042105; C:alpha-beta T cell receptor complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0045059; P:positive thymic T cell selection; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR015484; CD3_esu/gsu/dsu.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032052; Ig_4.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR PANTHER; PTHR10570:SF5; T-CELL SURFACE GLYCOPROTEIN CD3 DELTA CHAIN; 1.
DR PANTHER; PTHR10570; T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN / DELTA CHAIN; 1.
DR Pfam; PF16680; Ig_4; 1.
DR Pfam; PF02189; ITAM; 1.
DR SMART; SM00077; ITAM; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS51055; ITAM_1; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..171
FT /note="T-cell surface glycoprotein CD3 delta chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417285"
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..99
FT /note="CD3 gamma/delta subunit Ig-like"
FT /evidence="ECO:0000259|Pfam:PF16680"
SQ SEQUENCE 171 AA; 19222 MW; DAF1F9DD6AD8EA8F CRC64;
MARSRFLAGL ALATLLSHVS PFQEFVEEFE DKVVLNCTGI ITRLEGTMGI ELQDNHSLDL
GKRVLDPRGV YLCNETKEEG TTIYTLQVYY RMCQNCVELD PTTLAGIIVT DVIATLLLAL
GVYCFAGHET GRLPRAADTQ ALLRNDQLYQ PLRDRNDAQY SHLGESWPRS R
//