ID G1PPU5_MYOLU Unreviewed; 1577 AA.
AC G1PPU5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=C3 and PZP like alpha-2-macroglobulin domain containing 8 {ECO:0000313|Ensembl:ENSMLUP00000013050.2};
GN Name=CPAMD8 {ECO:0000313|Ensembl:ENSMLUP00000013050.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013050.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013050.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013050.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR EMBL; AAPE02039116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02039117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02039118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02039119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02039120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000013050; -.
DR Ensembl; ENSMLUT00000014345.2; ENSMLUP00000013050.2; ENSMLUG00000014332.2.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000162399; -.
DR HOGENOM; CLU_001634_1_0_1; -.
DR InParanoid; G1PPU5; -.
DR OMA; FIRECCT; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR022041; Methyltransf_FA.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF139; C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF12248; Methyltransf_FA; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1577
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003418188"
FT DOMAIN 454..623
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 747..838
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 504..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1577 AA; 174233 MW; 0158965DC87F74A6 CRC64;
MWGALLGPLL GLLLLLSPRD SVHAARPQAP GYLITAPSVF RSGVEEVISV TIFNSPREVM
VQAQLVAQGE AVAWSQGAML DKGTIKLKVP TGLRGQALLK VWGRSRQEEE GTLFHNQTSV
SVDARGASVF IQTDKPVYRP QHRVLISVFT VTPDLRPISE KLEAYILDPR GSRMMEWRHV
EPVCCGITNM TFPLSDQPVL GEWFIFVEMQ GHVYNKSFEV QKYALPKFEL LIDPPRYIRD
VDACETGTVQ ARYTFGKPVS GTLTINMTVN GVGYYSQEMG CPVLRTMKIH GSQDFHICVR
DMIPTDIPEH FRGTVSIWAA VTATDGSQQV AFDDSTPVQK QLVDIRYSKA TRKQFKPGLS
YMGMVELTYP DGSPAEGVTV QIRAELTPKD NIYTTESVSR GGLVAFEIPS IPTSAQHVWL
EAKVTALNGK PVGTQYLPSY LSLSSWYSPS QCYLQLQPPA RPLQVGEEAR FPVTSTCACN
LTLHYEVAAR GNIVLSGQQP ARITQQRSRR AAPEEPIRLT HLSETEPPPA PAAELSVCMT
SLQLSVTPSM VPLSRLLVFY VRENGEGVAD SVQFTVETFF ENQVSLTYSA NETQPGEVVD
LRVRAARGSC VCVAVVDKSV YLLRSGFRLT PAQVFQELEE YDVSDAFRVS WEDGPLWWAG
LAARRRRRSF VFLWLWGVIK DSGFAFAETG LVVMTDLVSL NHRQDGGLYT DEAVHTFQPH
TGSLMAVASS RQPPRAEKRR RTFFPETWVW RCLNISDPSG EETFRVQVPD SITSWVGEAV
GLSSAWGLGI ATPSLLKTFK PFFVDFTLPP QVVRGEQVKI PLSIYNYMGT CAEVYVQISV
PKGTRFVGHP GKRHLTKKLC VASGETEPIW VVLSFSDLGL SNITAKVLAY GETSCCRDGK
PSKQAEESYA DRVPAGRDHI RRSVIVEPEG APRTYTYSAF FCPNERVHIS TPNKYEFQYV
QRPQRLTRFD LSVRAHNDAR VALSPGPQDA AGMIEIVLGG HQNTRSWIST SKMGEPVAGT
HTAKILSWDE FRTFWISWHG GLIQVGYGPE PSNESVIMTW TLPKAPDVQF IGFSTGWGSM
GEFRLWRKME VDESYSEAFT LGVPHSAIPG SERAAASLIG DVMGPTLSHL SSLLRLPFGC
GEQNMIHFAP NVFVLKYLQK TRQLSPEVER ETTDHLVQVR ERERERERES RSLSWGTRGP
FTSRWLTAFV LKSFAQARSF IFIDPRELAA AKGWIVRQQQ VDGSFPATGR ILNKDIQGGI
HGAVPLTAYV VAALLETDVA SEVSTGAPRD QAGGTGEGFP LLACAGQAWV WVPCCAIPGA
CPGRWEAWGE LPSAIFMTLN NSHWGVAGGG ECEQGWWALW RRRTLIRGLE AEKSGAVGLR
GQRGDEGGGW AGSALPVSSE LLWDDMMCSD FIRECCTLNA TSGVHAEYRR ESPGGGQTWL
KPCKKNRADV TVVVILASPT CPCLAPPTPH THTPRAPRLG LLTPQIDVSY NVPDPVAKPS
FQLFVNLQEP EAERPRPPAP APSADDDDPA ADLHHQEYQV TLEVCTRWLH AGSSNMAVLE
VPLLSGLRAD IESLEQV
//
