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Database: UniProt
Entry: G1PQ15_MYOLU
LinkDB: G1PQ15_MYOLU
Original site: G1PQ15_MYOLU 
ID   G1PQ15_MYOLU            Unreviewed;       650 AA.
AC   G1PQ15;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   20-JUN-2018, entry version 45.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   Name=GLB1 {ECO:0000313|Ensembl:ENSMLUP00000013133};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013133, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000013133, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000013133}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of terminal non-reducing beta-D-
CC       galactose residues in beta-D-galactosides.
CC       {ECO:0000256|RuleBase:RU000675}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; AAPE02015308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G1PQ15; -.
DR   STRING; 59463.ENSMLUP00000013133; -.
DR   Ensembl; ENSMLUT00000014441; ENSMLUP00000013133; ENSMLUG00000014432.
DR   eggNOG; KOG0496; Eukaryota.
DR   eggNOG; COG1874; LUCA.
DR   GeneTree; ENSGT00390000006586; -.
DR   InParanoid; G1PQ15; -.
DR   OMA; GWGKGIV; -.
DR   OrthoDB; EOG091G006X; -.
DR   TreeFam; TF314816; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:Ensembl.
DR   Gene3D; 2.60.120.260; -; 3.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT   DOMAIN       41    356       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      543    617       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    188    188       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    268    268       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   650 AA;  73507 MW;  79B44BFEEDF67BC4 CRC64;
     LPGFSESLLL DVILLLRSQP QGGRDNASQK TFEIDYNHNC FRKDGQPFRY ISGSIHYFRV
     PRFYWKDRLL KMKMAGLNAI QIYVPWNFHE PQPGQYQFSE EHDVEHFIQL AHELGLLVIL
     RPGPYICAEW EMGGLPAWLL EKENIVLRSS DPDYLAAVDT WLGVILPKMK PLLYQNGGPI
     ITVQVENEYG SYFSCDYDYL RFLQKRFHYH LGNDVVLFTT DGEMEKLMQC GALQGLYATV
     DFGPGANITK AFLIQRKYEP KGPLINSEFY TGWLDHWGQP HSTVKTEVVA SSLQDILARG
     ANVNLYMFIG GTNFGYWNGA NMPYQPQPTS YDYDAPLSEA GDLTEKYFAV RDVIRKFEKV
     PEGPIPPSTP KFAYGKVALK KLKTVEEALN ILCPAGPVKS LYPLTFIQVK QYFGFVLYRT
     TLPEDCSEPT PLSSPHRGVH DRAYVSVDGV PQGVLDRNYV TTLNITGKAG ATLDLLVENM
     GRVNYGYYIN DYKGLISNLT LNSSILTDWM IFPLDIENAV YHLGGWHDND RSYRSKACAH
     SSNYTLPAFY VGNFSIPSGI PDLPQDTFIQ FPGWTKGQVW INGFNLGRYW PARGPQVTLF
     VPRHILVTSA PNTIAVLELE RAPCSDDPPE PCTVEFVDKP VISATVTYSH
//
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