ID G1PQ81_MYOLU Unreviewed; 422 AA.
AC G1PQ81;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=BCL2 like 13 {ECO:0000313|Ensembl:ENSMLUP00000013216.2};
GN Name=BCL2L13 {ECO:0000313|Ensembl:ENSMLUP00000013216.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013216.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013216.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013216.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR EMBL; AAPE02010154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02010155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02010156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02010157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02010158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02010159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PQ81; -.
DR STRING; 59463.ENSMLUP00000013216; -.
DR Ensembl; ENSMLUT00000014528.2; ENSMLUP00000013216.2; ENSMLUG00000014528.2.
DR eggNOG; ENOG502R6AP; Eukaryota.
DR GeneTree; ENSGT00390000015552; -.
DR InParanoid; G1PQ81; -.
DR OMA; MHEALQT; -.
DR TreeFam; TF330744; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR042398; BCL2L13.
DR PANTHER; PTHR15758; BCL-2-LIKE PROTEIN 13; 1.
DR PANTHER; PTHR15758:SF2; BCL-2-LIKE PROTEIN 13; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 397..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..157
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|Pfam:PF00452"
FT REGION 243..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46321 MW; 302F5E633E2AE46B CRC64;
GVQQDVASQS LDQEVLLKVK TEIEEELRFL DKEISEAFTN IGFDQHTSPV FSPANPVEDC
LAHLGERVSQ ELKEPLHKAL QVLLSQPVTY QTYRECTLET TVHASGWNKI LVPLVLLQQM
LLELTRRGQE PLSTLLQFGV TYLEDYAAEY IIQQGGWGTV FNLESEEEEY PEVVAEDSND
IYILPSDNSG QVSPPESPIV TTSWQSESLP ISLSASQSWH TESLPVSLGP ESWQQITMDP
EVKSLDSNGA GEKSENNSSN SDIVHVEKEE IPEGAEEAAV ASVVLSTREV QEAFPKAPAP
LLPHITATSL LGMRESDTEM TAVEKVSPAT SLFVELDEEE MKAAIIEPIE REEMIPILEP
TKTLLSEEMT IRKKSLMEGS YPAGEEKSMA LSEGKSILLF GGAAAFAILA VAIGVALALR
KK
//
