ID G1PRM5_MYOLU Unreviewed; 822 AA.
AC G1PRM5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Patched domain containing 3 {ECO:0000313|Ensembl:ENSMLUP00000013798.2};
GN Name=PTCHD3 {ECO:0000313|Ensembl:ENSMLUP00000013798.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013798.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013798.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013798.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AAPE02042767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PRM5; -.
DR STRING; 59463.ENSMLUP00000013798; -.
DR Ensembl; ENSMLUT00000015147.2; ENSMLUP00000013798.2; ENSMLUG00000015134.2.
DR eggNOG; KOG1933; Eukaryota.
DR GeneTree; ENSGT00940000158727; -.
DR HOGENOM; CLU_002359_2_1_1; -.
DR InParanoid; G1PRM5; -.
DR OMA; ERMGECM; -.
DR TreeFam; TF331806; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796:SF60; PATCHED DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 251..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 730..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..409
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 822 AA; 93673 MW; 764A9E1F7C366A15 CRC64;
RCHTNCLEAP LSRAFRWLGW EVGSHPWVFL LVPILLTTTL TTGFIYLPKD EEEDLEEQYT
PVGSPAKGER RFVQGHFTTN DSFHFSIFRM SSEVQFASIL VVSNSDTVLK QEILSEVSRL
DSAVQALNAT QEDGTPILFS QVCAKNQGIC VPSNPLLFAW QVNKKLDLKS ITFPIYIQNS
QPVSLAGTKA MRLQYYLRTQ EKENSEHSKR WLVHFLDEFS NIKESLALKM IRVVYFTSLS
RQLEFETTSK TVIPLFYVAY FLIILFSIAS CYRCDCVRNK IFVAVFGVIS TAFAVLSGFG
LMLFIGVPFV TIIKNAPFLV LGVGVDDMFI MISGWQKTKL VNSIRHRLSR TYSKVAVSIT
ITTVTNILAF YTGIMTSFRS IQYFCIYTGT TLFFCYLYTI TCFGAVLALD GKREVACLRW
LKKPDMADKK CSSLKRCCCL PFDSLPDELE TDIHPMNLFF RDYFGPFLTS TKTKLFVVLL
YISYLISSIY GCFQVQEGLD LRNLASDDSY ITPYFDVEEG HFPRYGPKVM VIVTETLDYW
DKNARQKLEK CLVDFENNGY VDKALTEFWL REYVQYMKDK KQDINDKNTF MKSISSFFVD
FPHFKYDVNI SSSHEIISSR AFIQTMDIST STKKKKMLIQ FRDLAKNCEI PLMVYNPAFI
YFDQYTAIIE NTIRNVIVAS AAMFVVSLLL IPHPLCSLWV TFAIGSVIVG VTGFMAFWKV
NLDSISMINL VICIGFSFDF SAHISYAFVS SSQPSVNLRT IEALYMLGYP VLQSAISTVI
GVSVLSAAKA YIFRTFFKIM FLVMVFGAAH GLIFIPVFLT FI
//
