ID G1PRM8_MYOLU Unreviewed; 866 AA.
AC G1PRM8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=5-oxoprolinase, ATP-hydrolysing {ECO:0000313|Ensembl:ENSMLUP00000013801.2};
GN Name=OPLAH {ECO:0000313|Ensembl:ENSMLUP00000013801.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013801.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013801.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013801.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the oxoprolinase family.
CC {ECO:0000256|ARBA:ARBA00010403}.
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DR EMBL; AAPE02068587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PRM8; -.
DR STRING; 59463.ENSMLUP00000013801; -.
DR Ensembl; ENSMLUT00000015150.2; ENSMLUP00000013801.2; ENSMLUG00000015135.2.
DR eggNOG; KOG1939; Eukaryota.
DR GeneTree; ENSGT00390000013463; -.
DR HOGENOM; CLU_002157_1_3_1; -.
DR InParanoid; G1PRM8; -.
DR OMA; HAMTVSV; -.
DR TreeFam; TF300520; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR InterPro; IPR049517; ACX-like_C.
DR InterPro; IPR008040; Hydant_A_N.
DR InterPro; IPR002821; Hydantoinase_A.
DR InterPro; IPR003692; Hydantoinase_B.
DR InterPro; IPR045079; Oxoprolinase_fam.
DR PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR Pfam; PF19278; Hydant_A_C; 1.
DR Pfam; PF05378; Hydant_A_N; 1.
DR Pfam; PF01968; Hydantoinase_A; 1.
DR Pfam; PF02538; Hydantoinase_B; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 16..183
FT /note="Hydantoinase/oxoprolinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF05378"
FT DOMAIN 202..501
FT /note="Hydantoinase A/oxoprolinase"
FT /evidence="ECO:0000259|Pfam:PF01968"
FT DOMAIN 517..681
FT /note="Acetophenone carboxylase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19278"
FT DOMAIN 705..865
FT /note="Hydantoinase B/oxoprolinase"
FT /evidence="ECO:0000259|Pfam:PF02538"
SQ SEQUENCE 866 AA; 92871 MW; F66BDF167582AD47 CRC64;
IRVPLMLRED PANYVDAPTE GIRRILEQEG GVLLPRDRPL DTSRIASIRM GTTVATNALL
ERQGERVALL VTRGFRDLLH VGTQAREDLF DLAVPMPEML YEEVLEVDER VVLYRGEPGS
GTPVKGCTGD LLEVQRPVDL GALRGKLEGL LDRGIRSLAV VLMHSYTWAQ HEQQVGALAR
EMGFTHVALS SEAMPMVRIV PRGHTACADA YLTPAIQRYV QGFCRGFQGQ LKDVQVLFMR
SDGGLAPMDA FSGSRAVLSG PAGGVVGYSA TTYQAEGGQP VIGFDMGGTS TDVSRYAGEF
EHVFEASTAG VTLQAPQLDI NTVAAGGGSR LFFRSGLFVV GPESAGAHPG PACYRKGGPV
TVTDANLVLG RLLPASFPCI FGPGEDQPLS PEASRKALEA VAADINSFLT NGPCPASPLS
LEEVAMGFVR VANEAMCRPI RALTQARGHD PSAHVLACFG GAGGQHACAI ARALGMDTVY
IHRHSGLLSA LGLALADVVH EAQEPCSLPY VPETFLQLDQ RLSRLEEQCV DALRAQGFPR
SQIRTEGFLH LRYQGTDCAL MVSAHQHPAT ARSPRAGDFG AAFVERYMRE FGFVIPERSV
VVDDVRVRGT GCSGLRLEDV AKAQMGPPRV DKMTQCYFEG GYQETPVFLL GELGYGHKLQ
GPCLIIDSNS TILVEPGCQA EVTETGDIRI SVGAETSGTV GAQLDPIHLS IFSHRFMSIA
EQMGRILQRT AISTNIKERL DFSCALFGPD GGLVSNAPHI PVHLGAMQET VQFQIQHLGA
DLHPGDVMLS NHPSAGGSHL PDLTVITPVF WPGQTRPVFY VASRGHHADI GGITPGSMPP
HSTALQQEGA VFLSFKLVQG GVFQEE
//
