ID G1PRR8_MYOLU Unreviewed; 802 AA.
AC G1PRR8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Oxidation resistance protein 1 {ECO:0000256|ARBA:ARBA00040604};
GN Name=OXR1 {ECO:0000313|Ensembl:ENSMLUP00000013847.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013847.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013847.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013847.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in protection from oxidative damage.
CC {ECO:0000256|ARBA:ARBA00037112}.
CC -!- SIMILARITY: Belongs to the OXR1 family.
CC {ECO:0000256|ARBA:ARBA00009540}.
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DR EMBL; AAPE02026241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PRR8; -.
DR STRING; 59463.ENSMLUP00000013847; -.
DR Ensembl; ENSMLUT00000015201.2; ENSMLUP00000013847.2; ENSMLUG00000015189.2.
DR eggNOG; KOG2372; Eukaryota.
DR GeneTree; ENSGT00940000155187; -.
DR HOGENOM; CLU_007095_2_0_1; -.
DR InParanoid; G1PRR8; -.
DR OMA; THIEGVC; -.
DR TreeFam; TF313530; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:Ensembl.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0071447; P:cellular response to hydroperoxide; IEA:Ensembl.
DR GO; GO:1900408; P:negative regulation of cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1902083; P:negative regulation of peptidyl-cysteine S-nitrosylation; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; LysM domain; 1.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR006571; TLDc_dom.
DR PANTHER; PTHR23354; NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED; 1.
DR PANTHER; PTHR23354:SF69; OXIDATION RESISTANCE PROTEIN 1; 1.
DR Pfam; PF01476; LysM; 1.
DR Pfam; PF07534; TLD; 1.
DR SMART; SM00257; LysM; 1.
DR SMART; SM00584; TLDc; 1.
DR SUPFAM; SSF54106; LysM domain; 1.
DR PROSITE; PS51782; LYSM; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 29..72
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 641..802
FT /note="TLDc"
FT /evidence="ECO:0000259|PROSITE:PS51886"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 90581 MW; 546FA29B210446D6 CRC64;
FFFSDTGQKK SLDKKDGRRM SFQKPKGTIE YTVESRDSLN SIALKFDTTP NELVQLNKLF
SRAVVTGQVL YVPDPDYVSS VESSPSLSPI SPLSPTSSEA EFDKATNPDA VHPKETTPSS
TFTGIRPARV VSSTSEEEEA FTEKFLKINC KYVTRGKGTV SGVLLVTPNN IMFDPHKSDP
LVQENGCEEY GIMCPMEEVM SAAMYKEILD SKIKESLPIE IDQLSGRDFC HLKKMTRSDA
DEIDSRIRDV VNHSASTAPR STEESLFEDV FTESELSLVR EELVSSDELR QGESSSASSE
SVQTVNQSGI ECSTVISEST TTLDQLKSDS GHSPNEVGAL SLKTDLNNLK MATKEGDQAT
DNVQEILDPK EGSINIKGNA DQDFLNENSL HQEEDEKESM PCGEATEFKL KQTVKGKQGK
EQTQDSETEV EELRKLWKKH TMQETKQQRD NIQQVSQKEI KHKIATVDIE GSSFLKEKRR
HQLHKFLRLR VGKPMRKTFV SQASATMQQY AQRDKKHEYW FAVPQERSDH LYAFFIQWSP
EIYAEDTGEY TREPGFIVVK KIEESETNED SSNEEAAREW EVVSVAEYHR RIDALNTEEL
RTLCRRLQIT TREDINSEQV APVKADLESE SFRPNLSDPS ELLQPDQIEK LTKHLPPRTI
GYPWTLVYGT GKHGTSLKTL YRTMIGLDTP VLMVIKDSDG QVFGALASEP FKVSDGFYGT
GETFVFTFRP EFEVFKWTGD NMFFIKGDMD SLAFGGGGGE FALWLDGDLY HGRSHSCKTF
GNNTLSKKED FFIQDIEIWA FE
//
