ID G1PRS1_MYOLU Unreviewed; 1234 AA.
AC G1PRS1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Zinc finger protein 687 {ECO:0000313|Ensembl:ENSMLUP00000013850.2};
GN Name=ZNF687 {ECO:0000313|Ensembl:ENSMLUP00000013850.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013850.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013850.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013850.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AAPE02030109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PRS1; -.
DR STRING; 59463.ENSMLUP00000013850; -.
DR Ensembl; ENSMLUT00000015204.2; ENSMLUP00000013850.2; ENSMLUG00000015198.2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156524; -.
DR HOGENOM; CLU_006283_1_0_1; -.
DR InParanoid; G1PRS1; -.
DR OMA; NGAPWSL; -.
DR TreeFam; TF329009; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR045914; Zn532-like.
DR InterPro; IPR041697; Znf-C2H2_11.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR47222; ZINC FINGER PROTEIN 532-RELATED; 1.
DR PANTHER; PTHR47222:SF2; ZINC FINGER PROTEIN 687; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF16622; zf-C2H2_11; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 533..551
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 703..730
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 825..852
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 856..884
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 991..1019
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1131..1159
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1197..1219
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 15..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..200
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1234 AA; 129365 MW; 7E87E900892CB68A CRC64;
MGDMKTPDFD DLLAAFDIPD IDANEAIHSG PEENEGPGGS GKPEPSVEGE SGEATAAAAG
DGPGVSTQAS DHDLSSGDIS VVSVIVKNTV CPEQSESLVA SSGGEGARAG GTIKEEPVGP
HLMQNGFGGP EPSLPGNPHS PTPPSGGTWK EKAIEGKAPL DLFAHFEPEP GEHPDPLPSS
VPSPLTEGTM TPPPFPSPFE LAEENGPALL PPGSPPPLGA LKQGSGSPLH PQGIARLDSG
SSPEAAGIPA SPSPQVAGMP FFKQSPGHQS PLASPKVPSC QPLKEEEEDQ GPVDKSPPAS
PQSPSSGAEA ADEDSNDSPA SSNSSRPLKV RIKTIKTSCG NITRTVTRVP SDPGPPAPLA
EGTFLAEANL LKLSSAVLTP ESPKVVNVQL GDGTRLKGTV LPVATFQNAS TAMLMAASVA
RKAVVLPGGT ATSPKTIAKN VLGLVPQALP KVEGRIGLGI GGQKVNGASV VIVQPSKPTT
VPGAGGGTVI SRTQSSLVEA FNKILNGKNL LPAYRPNLSP PAEAGLALPP TGYRCLECGD
AFSLEKSLAR HYDRRSMRIE VTCNHCARRL VFFNKCSLLL HAREHKDKGL VMQCSHLVMR
PVALDQMVGQ PDITPLLAVP PALGPPVLSA LGKGDGAIAT FAISTVAAEA PVLPLSAEPP
AAPATSAYTC FRCLECKEQC RDKAGMAAHF QQLGPPAPGA TSNVCPTCPM MLPNRCSFSA
HQRMHKNRPP HVCPECGGNF LQANFQTHLR EACLHFSRRV GYRCPSCAVV FGGVNSIKSH
IQTSHCEVFH KCPICPMAFK SAPSANAHLY TQHPSFPTQQ AKMIYKCAMC DTVFTHKPLL
SSHFDQHLLP QRVSVFKCPS CPLLFAQKRT MLDHLKNTHQ SGRSGEEIAG KGAGDPLPSP
KAEPEELAVS PGGAAPPIEE LSSSTEEDPP SSPEPPCSPK RPRRDLGNKG TKGGGGGPGG
WTCGLCHSWF PERDEYVAHM KKEHGKSVKK FPCRLCERSF CSAPSLRRHV RVNHEGIKRV
YPCRYCTEGK RTFSSRLILE KHVQVRHGLP LGDQSPGRGS VVVRGAGARA QGPGRKRRQS
SDSCSEEPDS TTPPAKSPRG GPGSGGPLRY RSGGSVEQSL MVGLRVDGGT QQCLDCGLCF
ASPGSLSRHR FISHKKKRGV GSASALGVGD GEEEAPPQLR SDPEGADSPL PASAGPLTCK
VCGKNCDSPL NLKTHFRTHG MAFIRARQGV SGDN
//
