ID G1PRV2_MYOLU Unreviewed; 682 AA.
AC G1PRV2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Extracellular matrix protein 2 {ECO:0000313|Ensembl:ENSMLUP00000013883.2};
GN Name=ECM2 {ECO:0000313|Ensembl:ENSMLUP00000013883.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013883.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013883.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013883.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02044521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02044522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02044523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02044524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006102261.1; XM_006102199.2.
DR AlphaFoldDB; G1PRV2; -.
DR STRING; 59463.ENSMLUP00000013883; -.
DR Ensembl; ENSMLUT00000015241.2; ENSMLUP00000013883.2; ENSMLUG00000015238.2.
DR GeneID; 102435373; -.
DR KEGG; mlf:102435373; -.
DR CTD; 1842; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159941; -.
DR HOGENOM; CLU_000288_186_2_1; -.
DR InParanoid; G1PRV2; -.
DR OMA; MTMYNRA; -.
DR OrthoDB; 5361311at2759; -.
DR TreeFam; TF330031; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR043184; ECM2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46544:SF1; EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR46544; EXTRACELLULAR MATRIX PROTEIN 2-RELATED; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..682
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417395"
FT DOMAIN 100..157
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 26..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..277
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 682 AA; 77433 MW; 6303AB1E637E516A CRC64;
MKFAGLSCVF LLIIFQIDFV QNDESPRKQR RKMYDRRLKK SSSPNHRSSR QPRIQQTTVV
MPAAALPMVN LHSSTEEEFE SFLTFPGVES SYNVLPGRKG RCSVNGVTMY NGAAWSPEPC
TTCLCADGRV LCDRTRCPPP RCQRAATPEG ECCPVCSDSE QREPPNSHHR QRPPPWVKLD
QALRKEELPA EEAEGMKETE DREQKKMSPE PGDRGRLPGQ GQRSRAEQRP GEEGRQARPH
GNTAREVEEE EVEEVEVEEE EEEEEEEEEE EEEEEETRGV LPVLSQLPAG APPRRRPALP
SGCSLSYRTI SCNDADLAQI PPLAAPEVTS LELAGNSITS IPDEAFNGLP NLERLDLSKN
SITSSGIGPE AFKHLKKLVH LNMNGNSLAE LPPELPPTLE ELRVSENKLR AIDEERLSGL
SRLVTLELEG NNLSETNLNP LAFRPLKSLS YLRLGRNRFR IIPQGLPASI EELYLENNQI
EEITEICFNH TRNINVIILC YNKIEENRIA PLAWINQENL ESIDLSYNRL YHVPSYLPKS
LLHLVLLGNR IERIPGYVFG HMEPGLEYLY LSFNNLSDDG LDRVSFYGAY HSLRELFLDH
NNLKSIPPGV QEMKALHFLR LNNNKIRHIL PEQICNAKED DDSTLEHLHL ENNYIKTREI
SSYAFSCIRS YSSIVLKPQK IK
//
