ID G1PS63_MYOLU Unreviewed; 1005 AA.
AC G1PS63;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Pleckstrin and Sec7 domain containing 3 {ECO:0000313|Ensembl:ENSMLUP00000013998.2};
GN Name=PSD3 {ECO:0000313|Ensembl:ENSMLUP00000013998.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013998.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013998.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013998.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR EMBL; AAPE02033657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02033658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02033659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02033660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02033661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PS63; -.
DR STRING; 59463.ENSMLUP00000013998; -.
DR Ensembl; ENSMLUT00000015364.2; ENSMLUP00000013998.2; ENSMLUG00000015363.2.
DR eggNOG; KOG0932; Eukaryota.
DR GeneTree; ENSGT00940000156591; -.
DR HOGENOM; CLU_011121_0_0_1; -.
DR InParanoid; G1PS63; -.
DR OMA; XDDEEKK; -.
DR TreeFam; TF319755; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF337; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 504..691
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 742..855
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..718
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1005
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 110263 MW; 615D33D6172101DA CRC64;
DHGGSTLLPP NVTNEFPEYG TMEDGGEGLR TSLEFDAESP PCCPQGQQGV QPHPSHHSGL
DSITEGPKDV GGGSSQSHLK EQSLQPIDSL ISALKATEAR IASGTLQATK VLDKDAVSSL
SVQQVDKELD TASHQTQTAN KLFPAGQEKP PDIPLSAEVT TGEGVLLRIQ EDLTVLLSGE
AQGELSRVTA NGRKGALRVQ EPACPGSSLG SPAAAHSSAG SIGFLREGRS ELQREHPGGC
DRGSSTGRPG RVKHVEFEGV EILWTGGKKR ETWQPADFET SSERTTSPES QGFSKVPSHL
ISSAGLCNSV GFTECVGADT WRGPSERPAT SSGTFPPAPL VEGGEDEVFL KENKDHLEEK
PELERDKERI LDHEEHFAGG EDDILGPGYT EDSTDVYSSQ FETILDNTSL YYSAESLETL
YSEPDSYFSF EMPLTPMIQQ RIKEGGQFLE RTSVGGQHDI LSISSDGGIV MGSSSEITNG
LSGAGESIYM KGTPEIAFWG SHAGVKTGLL ETHAEMGNTE ILEREPSESL SNGTSSNVEA
AKRLAKRLYQ LDRFKRSDVA KHLGKNNEFS RLVAEEYLKF FDFTGMTLDQ SLRYFFKAFS
LVGETQERER VLIHFSNRYF YCNPDTIASQ DGVHCLTCAM MLLNTDLHGH VSNIGKKMSC
QEFIANLQGV NEGGDFSKDL LKALYNSIKN EKLEWAVDDE EKKKSPSEGT DEKANGTHPK
TISRIGSTTN PFLDIPHDPN ATVYKSGFLA RKIHADMDGK KTPRGKRGWK TFYAVLKGTI
LYLQKDEYKP EKSLSEDDLK NAVSVHHALA SKATDYEKKP NVFKLKTADW RVLLFQAQSP
DEMQGWINKI NCVAAVFSAP PFPAAIGSQK KFSRPLLPAT TTKLSQEEQL KSHESKLKQI
TTELAEHRSY PPDKKVKAKE IDEYKLKDHY LEFEQTRYET YIGILKEGGK KLLGSNGSEA
PGLKKSHSSP SLNPDSSPVT AKVKRNVSER KDHRPETPSI KQKVT
//
