ID G1PSB8_MYOLU Unreviewed; 1141 AA.
AC G1PSB8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Nonsense-mediated mRNA decay factor {ECO:0000256|RuleBase:RU369098};
GN Name=SMG7 {ECO:0000313|Ensembl:ENSMLUP00000014060.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000014060.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000014060.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000014060.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC {ECO:0000256|RuleBase:RU369098}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369098}.
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DR EMBL; AAPE02019932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PSB8; -.
DR STRING; 59463.ENSMLUP00000014060; -.
DR Ensembl; ENSMLUT00000015430.2; ENSMLUP00000014060.2; ENSMLUG00000015417.2.
DR eggNOG; KOG2162; Eukaryota.
DR GeneTree; ENSGT00940000158333; -.
DR HOGENOM; CLU_009299_0_0_1; -.
DR InParanoid; G1PSB8; -.
DR OMA; WHQAGSA; -.
DR TreeFam; TF327119; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR019458; Est1-like_N.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696:SF5; NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7; 1.
DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161,
KW ECO:0000256|RuleBase:RU369098}; Nucleus {ECO:0000256|RuleBase:RU369098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1141
FT /note="Nonsense-mediated mRNA decay factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003418969"
FT DOMAIN 55..168
FT /note="Telomerase activating protein Est1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10374"
FT DOMAIN 171..430
FT /note="DNA/RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF10373"
FT REGION 556..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..699
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 127275 MW; 8F33FE463C44FDE3 CRC64;
LTALLFFLFR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL
WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR
VKSSQLGIIS HKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ
LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV
KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI
NLFQLHHLRD FSNETEQHSY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNK SQEESHNAYP
LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSST NATPLPEEFE
LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRQIRQQRLI SIGKWIADNQ PRLIQCENEV
GKLLFITEIP ELILEDPSEA KENLILQEAS IIESLAENGN PGLKSVLSTG RNLSNNCDTG
EKPVVTFKEN IKLREVNRDQ GRSFPPKEVK SQTELRKTPV SEARKTPVTQ TPSQASNSQF
IPIHHPGAFP PLPSRPGFPP PAYVISPPVA FPMGSGYTFP AGVSVPGTFL QPTAHSPAGN
QVQAGKQSHI PYSQQRPSGP GPMNQGPQQP QPPSQQPLTS LPAQPTAQST SQLQVQALAQ
QQQSPTKAVP ALGKSPPHHS GFQQYQQADA SKQLWNPPQV QGPLGKIMPV KQPYYLQTQD
PIKLFEPSLQ SPVMQQQPLE KKMKPFPMEP YNHNHSEVKV PEFYWDSSYS VADNRAVMAQ
QANMDRRGKR PPGVFRPEQD PVPRMPFEDP KGSPLLPPDL LKSLAALEEE EELIFSNPPD
LYPALLGPLA SLPGRSLFKS LLEKPSELMS HSSSFLSLTG FSLNQERYPN NSVFNEVYGK
NLTTSSKAEL NPAMAPQETS LYSLFEGTPW SPSLPASSDH STPASQSPHS SNPSSLPSSP
PTHNHNSVPF SNFGPIGAPD NRDRRAADRW KTDKPAMGGF GIDYLSATSS SESSWQQTST
PSGTWTGHGP SVEDSSAVLM ESLKSIWSSS MMHPGPSALE QLLMQQKQKQ QRGQGTMNPP
H
//
