ID G1PU54_MYOLU Unreviewed; 2247 AA.
AC G1PU54;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Polycystin family receptor for egg jelly {ECO:0000313|Ensembl:ENSMLUP00000014800.2};
GN Name=PKDREJ {ECO:0000313|Ensembl:ENSMLUP00000014800.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000014800.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000014800.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000014800.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02059793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000014800; -.
DR Ensembl; ENSMLUT00000016244.2; ENSMLUP00000014800.2; ENSMLUG00000016234.2.
DR eggNOG; KOG3599; Eukaryota.
DR GeneTree; ENSGT00940000162080; -.
DR HOGENOM; CLU_001765_0_0_1; -.
DR InParanoid; G1PU54; -.
DR OMA; KNHMWFS; -.
DR TreeFam; TF316484; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2247
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003418358"
FT TRANSMEM 1165..1185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1370..1388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1408..1431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1572..1592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1604..1626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1701..1725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1959..1980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2001..2024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2044..2063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2083..2105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2140..2166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..895
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1210..1327
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1440..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1468..1490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1506
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1535..1564
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2247 AA; 251875 MW; 0301A53DEED39853 CRC64;
MRPALLLLLL GLGLRCGGLP PPTATRGAPA GVPAAALRSF AGARGLHPLR GHARLGLRPR
VALGGGVLSG SGRGLCSSRG PAWRPRWHCL HVRVLLRALR ARRAAPTRVD PHLLARGGQR
SLRRLAPLRG LLRPRERTLH LGLVSPTDAS SASRGLHPDA GFEAQTKCPT DVNSGSWPAG
ESAESCRLLR QGTCSIKKLQ INRKPGLPAV LLTRRMDISL KATLQYDCPV AHTTQPNWKV
FSVPSLRHQP DWTKPLVVPG FQLGNDPTVM HIPKKTLSLG VYVFNFTVIL VPSLPQAAVV
KGSDSVYVSI LSDFLQAVLL GDVNMTIKFT DQLVLDGSTS VDPDVDDPLE GVQFSWFCTT
NSKNYNGDKI NVISKEVCLP KQVDLQLTWA SDPVLTMSPE TLRGGHVYFF RMVIQKAPRS
AYSDKRVRVL QARAPKASIS CIENCGRILV LSDRFSLSLN CPDCARSREV YKWSILRTSG
GEVAFDWLGQ TSTGRDSDSL SIKAFAFRNF SEAQFWIVLD LATWGGVNLS LMRSFTVNYA
PAIGDCKINP TSGIAFFTKF VVQCNNFKDQ NIPLTYKMIV SDLYDGFGEI SSLTENTLGP
ILYVGNDPRC PPSFLPVGGG DSHYSLKVFV QVYDALKAFS QVTFYVTVQA PTGQASPQAI
LTQLVNFTAG QNSEISTLLQ KQEFLFAGYL MYVVASVLNS MKPEPALQAD KAWLREHLVN
QSSLLPMNTL MEINQVVTVF AKLTQRTSEF PQVARQSATE RIWQANQAFL QHQQKAKNLH
SEQIETMSTG ILTSVSNILK MTDPHIIFVD PFRVIQSLAD TILAGKVPDD ESTVISSASF
TMYASKLEKG AVSNNILGNE RHCRNCFQPT LNVSSIPRLP ANAPVSVVFC EFADDPFPWL
NYQDSLAADV VGFRLTGISA NGDELELTPD VADVYVSRRN LSSAAFNLTV GPDHEPDNAD
ESSRMTTGAF RFEVDSRAVR ELLVHIVTEV TVQFTVLVYA GGQITPSALV ATFLVPHGIP
PIANQSGLFD LACAVSVPRL VCLPLSLLQV IAQRGHSPEC VIIMVLKAPH FVLQPSDKLV
RISLFSVRCL DMYGVQSDWT EDTCVLGEKT TWDRVHCVCR KARRARRQLA NVPLHFRYLT
AKVIVPPNPV DLRLEVIKNV TQNPVTLFVV LFILVTYIVL AFWALHRDET DQYLRDHAIV
LPDNDPYDNI CYLVTVFTGS RCGSGTRANV FVQLMGTQGT SDVHCLSHPH FKTLYRGSVH
TFLLTTRRDL GDIQSIRVWH NNEGHAPGWY LSRIKVENLF SRHIWLFMCR EWLSIETSLD
RTFPVTDPNT PLQRMDFLLI DATDNLGKNH LWFSVFAGVI SRGFNRLQRL SCCLAMLLST
LLCNIMFFNL DTEKQDKQDQ GNRYVRSMII GLESVMITLP VQVIITGLFT YSQRRPQATL
DQVTPQEYPE VAEESGHWEE RLERWHAQET ATEARSQEAR AQEARSQKSR SQKTRSQRRT
SKAGHSLRKK DSKGPHPPDA NANANKENMN SSPQVPSAQP PPPPQDQEPR DPFAPPPPPT
KPRTTLPGWS KWIAWFLVFA TSGVSSFFIV FYGLTYGYEK SIEWLFASLS SFCESVFLVQ
PSKIILLTGM RTNRLKYCKN LSWVSNYRYT EIQLQDLRLR PEEMHQRHQD LTRLRGSSMY
QPLTQDEVGI FRRKRALKRR ALLFLGHFLT HCIFLALLLG LVALLRRTDS FRYNQFIRSR
FSVDLATVTK LDDIYPWLHS ALLPLFHNDL HPTFLPDSSS KILGLPLLRQ VRATPGPKAC
RPAKRFPPNS IEGEIRCHPE YGADPEDTSD HPGFWKKVAK READKNTNGF TYKPPEERWV
YYSYGLLHTY GSGGYVFYFF PDQQQFNSTL RLRDLQSGRW LDEKTWAVIL ELTTLNADAG
LLGSTSVLFE VSQLGVVNAS ISVHSFSLVD LNRDTSAEVY LYVAILVFFV AYVVYEGYVI
TQNGASYLAN PNNLFNLALK CTLAVLIVLF LRKYFLATGI IQFYSSNPVD FIPFHAVAQV
DRTLGIVLGL LLFLTILKTL RYFRFFYHVR LAERVLQTAL PGICHVALLV FVYFFLFVAF
GHLVFGQHEW GYSTLIRATQ TVFSYCTAAL RNAEFSSNRA LGVLLLAAFV LLLICVLIHL
FAAVILSAYK ALRQPVYEEP SGEAEAIAYL CGKLRTVFGF LCCQPKAQEQ RELFVDMLYG
KPERRSSHYL GLKTRNINEK KMVYLVV
//
