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Database: UniProt
Entry: G1PVN9_MYOLU
LinkDB: G1PVN9_MYOLU
Original site: G1PVN9_MYOLU 
ID   G1PVN9_MYOLU            Unreviewed;      3629 AA.
AC   G1PVN9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   08-MAY-2019, entry version 66.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000015416};
GN   Name=CUBN {ECO:0000313|Ensembl:ENSMLUP00000015416};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015416, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000015416, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000015416}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AAPE02027084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02027085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02027086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02027087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02027088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02027089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000015416; -.
DR   Ensembl; ENSMLUT00000016915; ENSMLUP00000015416; ENSMLUG00000016887.
DR   eggNOG; KOG3714; Eukaryota.
DR   eggNOG; ENOG410ZPX7; LUCA.
DR   GeneTree; ENSGT00940000155299; -.
DR   InParanoid; G1PVN9; -.
DR   OMA; VMYLRFR; -.
DR   TreeFam; TF316224; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0005903; C:brush border; IEA:Ensembl.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
DR   GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0042953; P:lipoprotein transport; IEA:Ensembl.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   CDD; cd00041; CUB; 27.
DR   Gene3D; 2.60.120.290; -; 27.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 27.
DR   Pfam; PF00008; EGF; 3.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 3.
DR   SMART; SM00042; CUB; 27.
DR   SMART; SM00181; EGF; 8.
DR   SMART; SM00179; EGF_CA; 7.
DR   SUPFAM; SSF49854; SSF49854; 27.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 4.
DR   PROSITE; PS01180; CUB; 27.
DR   PROSITE; PS00022; EGF_1; 4.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 7.
DR   PROSITE; PS01187; EGF_CA; 3.
PE   4: Predicted;
KW   Calcium {ECO:0000256|SAAS:SAAS00909960};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00438935};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   3629       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003419115.
FT   DOMAIN      132    168       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      170    211       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      263    304       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      305    348       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      349    388       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      395    430       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      432    468       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      474    586       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      590    702       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      708    815       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      816    927       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      931   1041       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1047   1161       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1165   1277       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1278   1389       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1391   1506       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1510   1619       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1620   1734       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1738   1850       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1852   1963       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1978   2091       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2092   2213       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2217   2334       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2336   2448       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2452   2565       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2570   2690       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2693   2805       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2809   2923       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2924   3039       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3041   3154       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3163   3280       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3284   3399       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3401   3513       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     3517   3629       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   COILED      110    130       {ECO:0000256|SAM:Coils}.
FT   DISULFID    158    167       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    201    210       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    316    333       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    399    409       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    420    429       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    458    467       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   1620   1647       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID   2336   2363       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID   3041   3068       {ECO:0000256|PROSITE-ProRule:PRU00059}.
SQ   SEQUENCE   3629 AA;  397547 MW;  E22CEDE8623DEC6C CRC64;
     VRNMSSSFRW SVVILLTFAK SDGETGRLEL QSQTRITDLQ QPRMATERGN LVFLTGSAQN
     IEFKTGSLGK IKLNDEDLGE CLQQIQKNKD DIADLKRSAG GLPQNISSQI HQLNSKFVDL
     ERKVQSLQQT VDKKVCSSNP CQNGGTCLNL HDSFFCICPS QWKGPLCSAD VNECEIYAGT
     PFGCQNGATC INTVGSYSCL CSPETHGPQC ASKYDDCEAG SKALCVHGIC EDQVRIQAGQ
     PKYSCICDAG WTSPQNSSAC TLDRDECNLW PAPCSELVQC FNTPGSFYCG ACPTGWQGNG
     YYCQDVNECE TNNGGCSVAP PVECVNTPGS FHCQACPPGY QGDGRVCTLI DVCSVNNGGC
     HPQASCSPGP GSLPFCTCLP GYTGNGFGPN GCVQLSNMCL SRPCLNGQCI DTVSGYLCKC
     ESGWAGINCT ENINECLSNP CLNGGTCVDG INAFSCECTR FWTGFLCQIP QQVCGGSLSG
     VNGSFSYKSP DVGYVHDVNC FWVVRTEERK VLRITFTFFQ LESVSNCPHE FLQIHDGDSS
     AAFQLGRFCG SSTPHELLSS DNALYFHFYS EHLRNERGFT IRWETQQPEC GGILTGTYGS
     IKSPGYPGNY PPGRDCVWRV ITSPGLVITF AFGTLSLEHH DDCSKDYLEI RDGPLSQDPV
     LGKFCTTLSA PPLQTTGPFA RVHFHSDDQI SDQGFYITYL TSPSDPPCGG NYTDPEGVLS
     LDLNGPFTQN KHCIYVIQQP LGEQIQVNFT HVELEGQSGC SPSYIEVRDD DTLLGKVCGN
     ETLSHIKSIT NSIWIRFIID ASVEKAGFSA VYQVACGGEL TGEGVIRSPY YPNVYPGERI
     CRWAIHQPQS QVVLLNFTGF EIGSSAHCDT DYIEIGSSSI LGSTENKKYC GTDIPLLITS
     VYNFLHVIFV KSSSTENHGF MAKFSTKDLA CGKTLTEPTG IIQSPGHPNI YPHGISCTWY
     ISVQPGFLIN LIFRRFHLEF HYNCTSDYLE VYDTGSGTSL GRYCGKSVPP SLISSNSSLT
     LVFVADSDLA YEGFLIEYES TNASAVCLKD YTEESGTFTS PNFPNNYPNN WKCIYRITVG
     TSQQIALHFT NFSLEEEFGG KCLGDFVEIK DGGYETSPLL GKYCGSTTPP RIISHSNKLW
     LQFKSDIVVS SSGFSAYWDG SLTGCGGNLT TPTGTFTSPN YPMPYYHSSE CYWWLKASQG
     SPFELEFEEF HLEHHPNCTL DYLAVYDGPS TSSHLLTQLC GNEKPPLIRS SGDSMFLKLR
     TDEHQQGGGF LAKYHQTCEN VMIVNRTYGI LESIHYPNPY SDNQRCNWTI QATTGNTVNY
     TFLEFELENH LNCSHDYLEL YDGSRRIGRY CGADMPPSGS TAGSVLQVLF HTDGVGNKEK
     GFQMQWFVHG CGAELSGAMG SFSSPGYPNT YPPSKECIWY IHTAPGSSIQ LTIHDFDVEY
     HESCGFDVLE IYGGPDFHSP RIAQLCTRRS PENPMQVSST GHELAIRFKT DSMVSGRGFN
     VSWQAVPGGC GGIFQAPSGE IHSPNYPSPY RSNTDCSWVI RAERNHRVLL NFTDFDLEPQ
     DSCIIAYDGL SSATTRLARA CGRQQLTNPI TSSGNSLFVR FQSGPSRQSR GFQAHFRQVC
     GGYILTDSFD TISSPLFPAK YPDNQNCSWI IQAQPPFNHI TLSFTHFGLE SSTTCTQDFL
     EILDGNYDDA PLRGRYCGTS MPHPITSFSN ALTLRFISDS SVSFGGFHAT YAASSSACGG
     DFHMAEGTFD SPGYPEVYPS NVECVWNIVS SPGNRLQLSF ITFQLEDSQD CSRDFVEIRA
     ENATGHLVGR YCGNTLPLNY SSIVEHSLWI RFVSDGSGSG TGFQATFANI FGNDNIVGTH
     GKVASPLWPG NYPHNSDYQW IVNVNASQVV HGRILEMDIE STHNCYYDKL RIYDGAGIHS
     RPIGTYCGAQ TDSFSSTGSS LTFQFSSDSS VSGKGFLLEW FAVDAAVGPL PTIATGACGG
     FLRTGEAPAF LFSPGWPQNY GNRADCVWLI QAPDSTVELN ILSLDIESHG TCNYDKLVIR
     DGDNNMAQQL AVLCGREIPG PIRSTGEYMW LRFTSDFSVT RAGFNASFHK SCGGYLHANR
     GIITSPNYPE TYPPNLNCSW HVLVQSGLTI AVHFEQPFQI ANGDSSCNEG DYLGLRNGPD
     ISSPPMGPHG GNGHFCGSRP SSTLFTSDHQ MFVQFISDNS NGGQGFKIRY EAKSLACGGN
     IYIHDVDSVG YVTSPNHPDN YPQHADCIWL IAAPPGKLIR LQFEDQFNIE VTPNCTSNYL
     ELRDGADSNA PIISKLCGTS LPRSQLSSGE VIYLRFRSDN NSTHVGFKAK YSIAQCGGTL
     TGQSGVIQSV GYPTLAYSDN LLCEWHLRGP SGHYLTIHFE DFNLQNSSGC EKDFVEIWEN
     HTSGNLLGRY CGNIIPDSVD TSSNVALVRF VTDDSLTASG FRLRFESSLE ECGGDLQGPT
     GTFTSPNYPN PNPHGRICEW RITVQEGRQV TLTFNNLRLE AHPSCNSERV TVFNGIRSNS
     PVLGKLCSSV NISDEIKSSG NTMKVIYFTD GSRPYGGFSA SYTSSEDAVC GGALTNSPEG
     NFTSPGYNGV SNYSRNLNCE WTLSNPNQGN SSIYIHFENF YLESHQDCQF DVLEFRVGNA
     DGPLIWRLCG PVASTVPLVI PYSQVWIHFV TNERVEHTID KNFHNVTNLI SDCGGIQTGE
     SGVITSPNYP ASYDSLTHCA WLLEVPQGDT ITLTFSDFDI ESQSTCAWDS VTVRNGGSPG
     SPIIGHYCGT SSPSPIQSGS NQLVVIFNSD HSVQNGGFYA TWSMHTLGCG GILHSDNGTI
     RSPHWPQNFP ENSRCSWTVI THESNHLEIS FDNNFLIPSG DGQCHNSFVK VWAGTEEMDK
     ALLATSCGNV APGAIITPRN AFTAVFQSQE APAPGFSASF VSRCGSNFTK PSGYIISPNY
     PKQYDNNMNC TYFIEANPLS VVFLTFVSFH LEARSAVTGS CDNDGLHIIR GHSVASTPFA
     TVCGDEVLSP VTISGPVLLN FYSNSHTTDF GFKLSYQITS CGGVFNFSTG IIKSPAYSYS
     DYPNNMYCLY NITVRDNKVI LLKFTHFDVA LSTSCSQDYL AIYDGYNISD PLLGKFCGSK
     LPPNVKSSNN SMLLVFKTDA FQTARGWVIT FRQTLDTGPQ QGCGGYLTGS NSTFASPDSD
     ANGRYDKNLN CIWFIIAPVN KLIKLTFNTF ALESASALQR CIYDYVKLYD GESENAKLAG
     TFCGSTVPAP FVSSGNFLTV QFVSDISLER EGFNATYTFI NMICGGTYNA TWTPQNISSP
     NASNPDVPLS TCTWVFEAPP HQQVEITVWA FQLQSRDCHQ NYLEFQDTPE SSGNARIHLC
     GRNATAVPTF YSSMSTAIVI FKSEVFNDNS RVSFTYQIAG CNRNYKKAFG NLKSPGWPAN
     YNNDMDCTVT LTAPQNHSIS LFFHSFGIED SSECRHDFLE VRNGSDSSSP LLGTYCGTLL
     PNPIFSQNNE LYLRFKSDSA TSSRGYEIIW TSSPSGCGGT LYGDHGSFTS PGYPGTYPNH
     THCEWAITAP AGRLVTVNFY FISIDDPGDC VQNYLILYDG PDVNSPSSGP YCGTDTNIAP
     FVASSHRVFI EFHAEYAVRP SAIQLTWDS
//
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