ID G1PVZ1_MYOLU Unreviewed; 3082 AA.
AC G1PVZ1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 12-AUG-2020, entry version 52.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000015541};
GN Name=CENPF {ECO:0000313|Ensembl:ENSMLUP00000015541};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015541, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000015541, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000015541}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2011) to UniProtKB.
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DR EMBL; AAPE02019978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006089936.1; XM_006089874.2.
DR RefSeq; XP_014312315.1; XM_014456829.1.
DR STRING; 59463.ENSMLUP00000015541; -.
DR Ensembl; ENSMLUT00000017046; ENSMLUP00000015541; ENSMLUG00000017038.
DR GeneID; 102425437; -.
DR CTD; 1063; -.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_000551_0_0_1; -.
DR InParanoid; G1PVZ1; -.
DR OMA; YNAQLVQ; -.
DR OrthoDB; 205405at2759; -.
DR TreeFam; TF101133; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1894..2035
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2125..2264
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2308..2439
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2950..2994
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 211..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2868..3082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..384
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 418..459
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 467..501
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 523..650
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 686..720
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 725..766
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 837..871
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 904..955
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 967..987
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1027..1054
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1080..1157
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1201..1242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1285..1319
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1395..1422
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1547..1617
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1624..1644
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1791..1853
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1891..1911
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1919..1953
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1968..1998
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2010..2037
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2045..2079
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2101..2121
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2136..2272
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2290..2359
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2367..2401
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2409..2454
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2462..2482
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2490..2597
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2605..2703
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2733..2760
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2768..2816
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2824..2855
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1676..1709
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2869..2887
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2896..2914
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2936..2952
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2980..3029
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3066..3082
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3082 AA; 354087 MW; 0358ECBD470000A1 CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGTNLKRENQ SLMEICENLE KAKQKISHEL QVKESQMNFQ EGQLSSSKKQ IEKLEQELKR
CKSELERSQQ AAQSADVSLN PCNTPQKIFT TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKASQAIPQN TMNHRDIARH QASSSVFSWQ QEKTPSRLSS SVLQTPSRRD
FSASHFSGEQ EVTPSRSTLQ AGKRDANSSF CDNSSNSHLL DQLKAQNQEL RGKIGELELR
LQGQEKEMKG QVNKWQELQL QLEKAKVELN EKEKVLNKSR DELVRTSAQY DQASAKCTAL
EQKLKKLTED LSCQRQNAES ARCSLEQKLK EKEKEFQEEL CRQQRSFQTL DQECTQMKVK
LTQELQQAKN AHNILQAELD KVTSVKNQLE NKLEEFKQNA CRTEQALQAS QSKENELRRS
CEEMKKENSF LKSQSEQSAR EVCHLQEELK KTKQCLTHSQ NFAEEMKAKN TSQETMLKDL
QEKINRQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLSEKLSK TERESEALLS
ALEVKKKEFE ELKEEKTQFS HWKNENEQLI KQMESDKESL LSKINQLETC LKTQKIKSNE
YNERVSILEM ERENISVEVR NLHNMIDSKT VEVEAQKQAY AELQQKAEFS DQKHKKEMEN
MCVKVSELTG QVEDLKHKLQ LLSSEITNKD QRYQDLHAEY ERLRDLLKSS DSLVANEAHH
RNLLAFEQQS AVNNSFANIG EQGSMPSERS DCHVEADQSP ENSAVLQNKV ISLEFSLESQ
KQMNSDLQKQ CEELVQIRGE IEENLVRAEQ MHQSFVAETS QRINKLQEDT SVHQNVVTET
LVALENKDRE VQLLNGKLES EQAEIQELKK SNHLLQESLK ELQLLSETLS SEKKEMSSIL
SLNKKKIEEL TQENGTLKEL NATLNQEKMD LLQKSESISQ CIVEGEKSIS ELSNQYEQER
LILLQRCEET GNAFEDLSEK YKAAQETNSK LESVLNECTS VSEDRKTELE QLKETFAREH
QAFVAKLALA EERNQNLIQE LESLQGDLRA EIVEIQNNSK SEADDLKQEI RTLKEEHTKM
QKEVNALSQE NEQLMNLMKM KHEHRNLELD PINDSVTERD SEKSKCHVQL PMELEVKDTS
QDNYVAQLEQ LEAKIRNMEL QLEESEKEKK YLQHELQKIN RELESRNLLQ DIQSQEISGL
KDCEVDTEEK YMSMLHELST SQKDNEQLQC SLQMALNKLN ELETMCEMLR SEKFELMSEL
NDSRSECITA TSKMANVEKL VSEVKILNDE NGHCQDKLVE EMLEGECGEQ QNSETSVSLN
PLDNSHIYEH LTLSNKEVQT HFAELQEKFS SLQSEHKTLH DQHSQMSSKM SELQSYVDVL
KAENLVLSMS LRNSPGDLVK EGKMESRERR SLSLSFSCVA DSPSLTSLGE LSFCKDLLEQ
TGETSLWNSL EGNVSTNQSH LEEVSCSSLE EEDLPKTAVP SASEKSVEEL EILCQIYQQS
LKKLEEKIES QEIMKKKEIE ELKQLLNSEM EELDCLRKQH LSENEQWQQK LASVTMEMES
KLAAEKKQTE HLSLELEVAR LQLQGLDLST RSFLGTDLED AIQGGNDNCD TNESEECTTS
ETKERTPKQD MHPMCEKEAQ QDLSLEEEKS TKPGAVLQAG ECSQELSPET SSDFPLEDKT
QDFPECISKS SLSGPNPLVP MDFLEAQVTT QNLQLQVKEI SNENLRLLHV IEERDKNVEI
LLSEIKELDS RLNLQEVQLT TKIETCRELE ETVEELKKEK SNLMEKLESF SCDNLEFHQR
VESLEGLNCS LEMGTAKLSH EVTQDNVAKV NDHWRERFLE VENELQRIKL EKGSIEHHAH
SVEADIERVQ TEKLQLEKDY ESKQQVISHL EEELSVVTSE RNRLHGELDT LSKENKELDL
MSEKMKEKIR ELESHQEECL QHIEVVGDEL KDKTQLLQNL SSDNARLQEQ LQSLEKDSHT
LSLGKSELEN QIGQLNNEKD LLLRDSESLK TKFHELEQEK LTIAKALEAA VMEKGEVAMR
LNSTQDEVHQ LRSGIEKLRV RIEADEKKQL HVLEKLKESE RKNDSLQDKL ENLERELQMA
EENQEMVILD AENSKAEVET LKTQIELTTE RLKALESNLV AIQSEKENLT KQLQEKQGQV
SELDTLLSSL KNLLEEKEQE NMQTKEESKA AVEMLQTELK ELNEEVSTLF DDQETREVRA
QSLGSPVQVV QQLRNSIEKL KIHLETDEKK QQESKHHADL LKDRVENLER ELEMSRKNHE
RAILEAENSK AEVDTLTAKI EEMAPNLRDL ELNLVNIRSE KENLTKELEK EQGRVSELET
LNSSFENLLQ VREQEKLQLK EESKLAEERL QAQLKELKEK VAALCDDQET WKAKQQDLSG
QVDYLEHEKS KLLQSLDEAK SNYTILQSSV NGLIQEVEDG KQKLQKKDEE IHVLKNQIQD
REQLVSKLSQ VEGEQQVWKK QKADLENLTV ELEQKIQGLQ STNDTLQHTF EALQTSYKDL
EKELELTKME KISLVEKVDT MTLKETELQR EIHAMMQKMT GLEEEVSGEK NRLTEELNLM
SEEIKNSKGQ LKEFMLENSE LKRSLDCLQK DQMEKQEKMR EEIAGYQLQL QEAEKKHQTL
LLDTNKQHEM EIQTYREKLA SKEACLGSQK VEIDLLKSSK EELNNSLKAA TELLEELKRT
KTDNLKYASQ LKKEKERAQG KIKLLIKSCK QLEEEKELLQ KELSRLEDAA RGKQNSGPVV
DANVDELKTE VKELKETLEE KSKEAEEYLD KYCALLISYE KLERAKEMLE TQQSQPNVQS
SPSPESVVPG SAPVPSVTEK QKSSGQSKGS GKRQRNSGIW EDGGGAAPST PDSFPKRSRK
AVRSGAHPAE DAEDAEFELE GLPEVVKKGF ADIPTGKTSP YVLRRTTMAT RTSPRLAAQK
STPSPSKPTA GGSRSQKIKV AQQSPADSGS IFREPPARPL SVSNLPERRL AGSPREGLRS
KRGQPTPSPE AGTKPNENCR VQ
//
