GenomeNet

Database: UniProt
Entry: G1PVZ1_MYOLU
LinkDB: G1PVZ1_MYOLU
Original site: G1PVZ1_MYOLU 
ID   G1PVZ1_MYOLU            Unreviewed;      3082 AA.
AC   G1PVZ1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   12-AUG-2020, entry version 52.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000015541};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSMLUP00000015541};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015541, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000015541, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000015541}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AAPE02019978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006089936.1; XM_006089874.2.
DR   RefSeq; XP_014312315.1; XM_014456829.1.
DR   STRING; 59463.ENSMLUP00000015541; -.
DR   Ensembl; ENSMLUT00000017046; ENSMLUP00000015541; ENSMLUG00000017038.
DR   GeneID; 102425437; -.
DR   CTD; 1063; -.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; G1PVZ1; -.
DR   OMA; YNAQLVQ; -.
DR   OrthoDB; 205405at2759; -.
DR   TreeFam; TF101133; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1894..2035
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2125..2264
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2308..2439
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2950..2994
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          211..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1662..1740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2868..3082
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          280..384
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          418..459
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          467..501
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          523..650
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          686..720
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          725..766
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          837..871
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          904..955
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          967..987
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1027..1054
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1080..1157
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1201..1242
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1285..1319
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1395..1422
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1547..1617
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1624..1644
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1791..1853
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1891..1911
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1919..1953
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1968..1998
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2010..2037
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2045..2079
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2101..2121
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2136..2272
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2290..2359
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2367..2401
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2409..2454
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2462..2482
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2490..2597
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2605..2703
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2733..2760
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2768..2816
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2824..2855
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1676..1709
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2869..2887
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2896..2914
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2936..2952
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2980..3029
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3066..3082
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3082 AA;  354087 MW;  0358ECBD470000A1 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
     EGTNLKRENQ SLMEICENLE KAKQKISHEL QVKESQMNFQ EGQLSSSKKQ IEKLEQELKR
     CKSELERSQQ AAQSADVSLN PCNTPQKIFT TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKASQAIPQN TMNHRDIARH QASSSVFSWQ QEKTPSRLSS SVLQTPSRRD
     FSASHFSGEQ EVTPSRSTLQ AGKRDANSSF CDNSSNSHLL DQLKAQNQEL RGKIGELELR
     LQGQEKEMKG QVNKWQELQL QLEKAKVELN EKEKVLNKSR DELVRTSAQY DQASAKCTAL
     EQKLKKLTED LSCQRQNAES ARCSLEQKLK EKEKEFQEEL CRQQRSFQTL DQECTQMKVK
     LTQELQQAKN AHNILQAELD KVTSVKNQLE NKLEEFKQNA CRTEQALQAS QSKENELRRS
     CEEMKKENSF LKSQSEQSAR EVCHLQEELK KTKQCLTHSQ NFAEEMKAKN TSQETMLKDL
     QEKINRQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLSEKLSK TERESEALLS
     ALEVKKKEFE ELKEEKTQFS HWKNENEQLI KQMESDKESL LSKINQLETC LKTQKIKSNE
     YNERVSILEM ERENISVEVR NLHNMIDSKT VEVEAQKQAY AELQQKAEFS DQKHKKEMEN
     MCVKVSELTG QVEDLKHKLQ LLSSEITNKD QRYQDLHAEY ERLRDLLKSS DSLVANEAHH
     RNLLAFEQQS AVNNSFANIG EQGSMPSERS DCHVEADQSP ENSAVLQNKV ISLEFSLESQ
     KQMNSDLQKQ CEELVQIRGE IEENLVRAEQ MHQSFVAETS QRINKLQEDT SVHQNVVTET
     LVALENKDRE VQLLNGKLES EQAEIQELKK SNHLLQESLK ELQLLSETLS SEKKEMSSIL
     SLNKKKIEEL TQENGTLKEL NATLNQEKMD LLQKSESISQ CIVEGEKSIS ELSNQYEQER
     LILLQRCEET GNAFEDLSEK YKAAQETNSK LESVLNECTS VSEDRKTELE QLKETFAREH
     QAFVAKLALA EERNQNLIQE LESLQGDLRA EIVEIQNNSK SEADDLKQEI RTLKEEHTKM
     QKEVNALSQE NEQLMNLMKM KHEHRNLELD PINDSVTERD SEKSKCHVQL PMELEVKDTS
     QDNYVAQLEQ LEAKIRNMEL QLEESEKEKK YLQHELQKIN RELESRNLLQ DIQSQEISGL
     KDCEVDTEEK YMSMLHELST SQKDNEQLQC SLQMALNKLN ELETMCEMLR SEKFELMSEL
     NDSRSECITA TSKMANVEKL VSEVKILNDE NGHCQDKLVE EMLEGECGEQ QNSETSVSLN
     PLDNSHIYEH LTLSNKEVQT HFAELQEKFS SLQSEHKTLH DQHSQMSSKM SELQSYVDVL
     KAENLVLSMS LRNSPGDLVK EGKMESRERR SLSLSFSCVA DSPSLTSLGE LSFCKDLLEQ
     TGETSLWNSL EGNVSTNQSH LEEVSCSSLE EEDLPKTAVP SASEKSVEEL EILCQIYQQS
     LKKLEEKIES QEIMKKKEIE ELKQLLNSEM EELDCLRKQH LSENEQWQQK LASVTMEMES
     KLAAEKKQTE HLSLELEVAR LQLQGLDLST RSFLGTDLED AIQGGNDNCD TNESEECTTS
     ETKERTPKQD MHPMCEKEAQ QDLSLEEEKS TKPGAVLQAG ECSQELSPET SSDFPLEDKT
     QDFPECISKS SLSGPNPLVP MDFLEAQVTT QNLQLQVKEI SNENLRLLHV IEERDKNVEI
     LLSEIKELDS RLNLQEVQLT TKIETCRELE ETVEELKKEK SNLMEKLESF SCDNLEFHQR
     VESLEGLNCS LEMGTAKLSH EVTQDNVAKV NDHWRERFLE VENELQRIKL EKGSIEHHAH
     SVEADIERVQ TEKLQLEKDY ESKQQVISHL EEELSVVTSE RNRLHGELDT LSKENKELDL
     MSEKMKEKIR ELESHQEECL QHIEVVGDEL KDKTQLLQNL SSDNARLQEQ LQSLEKDSHT
     LSLGKSELEN QIGQLNNEKD LLLRDSESLK TKFHELEQEK LTIAKALEAA VMEKGEVAMR
     LNSTQDEVHQ LRSGIEKLRV RIEADEKKQL HVLEKLKESE RKNDSLQDKL ENLERELQMA
     EENQEMVILD AENSKAEVET LKTQIELTTE RLKALESNLV AIQSEKENLT KQLQEKQGQV
     SELDTLLSSL KNLLEEKEQE NMQTKEESKA AVEMLQTELK ELNEEVSTLF DDQETREVRA
     QSLGSPVQVV QQLRNSIEKL KIHLETDEKK QQESKHHADL LKDRVENLER ELEMSRKNHE
     RAILEAENSK AEVDTLTAKI EEMAPNLRDL ELNLVNIRSE KENLTKELEK EQGRVSELET
     LNSSFENLLQ VREQEKLQLK EESKLAEERL QAQLKELKEK VAALCDDQET WKAKQQDLSG
     QVDYLEHEKS KLLQSLDEAK SNYTILQSSV NGLIQEVEDG KQKLQKKDEE IHVLKNQIQD
     REQLVSKLSQ VEGEQQVWKK QKADLENLTV ELEQKIQGLQ STNDTLQHTF EALQTSYKDL
     EKELELTKME KISLVEKVDT MTLKETELQR EIHAMMQKMT GLEEEVSGEK NRLTEELNLM
     SEEIKNSKGQ LKEFMLENSE LKRSLDCLQK DQMEKQEKMR EEIAGYQLQL QEAEKKHQTL
     LLDTNKQHEM EIQTYREKLA SKEACLGSQK VEIDLLKSSK EELNNSLKAA TELLEELKRT
     KTDNLKYASQ LKKEKERAQG KIKLLIKSCK QLEEEKELLQ KELSRLEDAA RGKQNSGPVV
     DANVDELKTE VKELKETLEE KSKEAEEYLD KYCALLISYE KLERAKEMLE TQQSQPNVQS
     SPSPESVVPG SAPVPSVTEK QKSSGQSKGS GKRQRNSGIW EDGGGAAPST PDSFPKRSRK
     AVRSGAHPAE DAEDAEFELE GLPEVVKKGF ADIPTGKTSP YVLRRTTMAT RTSPRLAAQK
     STPSPSKPTA GGSRSQKIKV AQQSPADSGS IFREPPARPL SVSNLPERRL AGSPREGLRS
     KRGQPTPSPE AGTKPNENCR VQ
//
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