ID G1PWW5_MYOLU Unreviewed; 700 AA.
AC G1PWW5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=UV radiation resistance associated {ECO:0000313|Ensembl:ENSMLUP00000015911.2};
GN Name=UVRAG {ECO:0000313|Ensembl:ENSMLUP00000015911.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015911.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000015911.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000015911.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02045878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02045879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02045880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02045881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02045882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02045883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006102947.1; XM_006102885.2.
DR AlphaFoldDB; G1PWW5; -.
DR STRING; 59463.ENSMLUP00000015911; -.
DR Ensembl; ENSMLUT00000017454.2; ENSMLUP00000015911.2; ENSMLUG00000017450.2.
DR GeneID; 102433214; -.
DR KEGG; mlf:102433214; -.
DR CTD; 7405; -.
DR eggNOG; KOG2896; Eukaryota.
DR GeneTree; ENSGT00390000012877; -.
DR HOGENOM; CLU_009375_2_0_1; -.
DR InParanoid; G1PWW5; -.
DR OMA; HVDQNCV; -.
DR OrthoDB; 5481315at2759; -.
DR TreeFam; TF323546; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0000421; C:autophagosome membrane; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0070418; C:DNA-dependent protein kinase complex; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0035032; C:phosphatidylinositol 3-kinase complex, class III; IEA:Ensembl.
DR GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR GO; GO:0007098; P:centrosome cycle; IEA:Ensembl.
DR GO; GO:0097680; P:double-strand break repair via classical nonhomologous end joining; IEA:Ensembl.
DR GO; GO:0051684; P:maintenance of Golgi location; IEA:Ensembl.
DR GO; GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0032801; P:receptor catabolic process; IEA:Ensembl.
DR GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:Ensembl.
DR CDD; cd00030; C2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR018791; UV_resistance/autophagy_Atg14.
DR PANTHER; PTHR15157; UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN; 1.
DR PANTHER; PTHR15157:SF5; UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN; 1.
DR Pfam; PF10186; ATG14; 1.
DR Pfam; PF00168; C2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 24..150
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 231..307
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 500..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 77969 MW; 765C21C6867B50E1 CRC64;
MSASASIGGT VPPPPPGPAA AALPPGSAAR ALHVELPSQQ RRLRHLRNIA ARNIVNRNGH
QLLDTYFTLH LCNSEKIYKE FYRSEVIKNS LNPTWRSLDF GLMPDRLDTS VSCFVVKIWG
GKEAAYQLLI EWKVCLDGLK YLGQQIHARN QNEIIFGLND GYYGAPYEHK GYSNAQKNIL
LQVDQNCVRN SYDVFSLLRL HRAQCAIKQT QVTVQKIGKE IEEKLRLTST SNDLKKESEC
LQLNILVLRN ELERQKKALG REMALLHKQQ IALQDKGSTF STEHLKLQLQ KESLNELRKE
CTAKRELFLK TNAQLTIRCR QLLSELSYIY PIDLNEHKDY FVCGVKLPNS EDFQAKDDGS
IAVALGYTAH LVSMISFFLQ VPLRYPIIHK GSRSTIKDNI NDKLTEKERE FPLYPKGGEK
LQFDYGVYLL NKNIAQLRYQ HGLGTPDLRQ TLPNLKNFME HGLLVRCDRH HTSSAIPVPK
RQSSIFGGAD GGFSGGIPSP DKGHRKRASS ENERLHYRTP PPSYNSAVAQ PGPTTPSLGE
SERKTTTLSS SLDTSLDFSK ENQKKGVDLG NSLNVGPVSV NTGQEQGEAL PGHPATVNGA
LLPSEQAGAA SAQLPGEFHP GSEAELCCAV EQAEEIIGME ATGFTSSDQL EAFNCIPVDS
AVAVECDEQV LGEFEEFSRR IYALNENVSS FRRPRRSSDK
//
