ID G1PX10_MYOLU Unreviewed; 382 AA.
AC G1PX10;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Paralemmin-1 {ECO:0000256|ARBA:ARBA00040790};
DE AltName: Full=Paralemmin {ECO:0000256|ARBA:ARBA00041963};
GN Name=PALM {ECO:0000313|Ensembl:ENSMLUP00000015962.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015962.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000015962.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000015962.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with dopamine receptor DRD3.
CC {ECO:0000256|ARBA:ARBA00038823}.
CC -!- SUBCELLULAR LOCATION: Apicolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00037796}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00037796}. Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00037871}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00037871}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004342}. Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, filopodium membrane
CC {ECO:0000256|ARBA:ARBA00004527}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004527}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00037829}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00037829}. Membrane
CC {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}.
CC -!- SIMILARITY: Belongs to the paralemmin family.
CC {ECO:0000256|ARBA:ARBA00005756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02043778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PX10; -.
DR STRING; 59463.ENSMLUP00000015962; -.
DR Ensembl; ENSMLUT00000017509.2; ENSMLUP00000015962.2; ENSMLUG00000017505.2.
DR eggNOG; ENOG502QQ2W; Eukaryota.
DR GeneTree; ENSGT00940000160580; -.
DR HOGENOM; CLU_038333_2_0_1; -.
DR InParanoid; G1PX10; -.
DR OMA; VDGSTMM; -.
DR TreeFam; TF105402; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016327; C:apicolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044309; C:neuron spine; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0031750; F:D3 dopamine receptor binding; IEA:Ensembl.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0071257; P:cellular response to electrical stimulus; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0060074; P:synapse maturation; IEA:Ensembl.
DR InterPro; IPR004965; Paralemmin.
DR PANTHER; PTHR10498:SF6; PARALEMMIN-1; 1.
DR PANTHER; PTHR10498; PARALEMMIN-RELATED; 1.
DR Pfam; PF03285; Paralemmin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REGION 21..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 41384 MW; A2A73AF30852A9B4 CRC64;
RRVLGGETTF PQERLQAIAE KRKKQAEIEN KRRQLEDDRR QLQHLKSKAL RERWLLEGTP
SSASEGDKDM RRQMQEDEQK ARHLEESISR LEQEIEVLEN ADARPAAAKE TVAAPSPAKQ
TQKAEVVLNS QQTPVGTPKE AAKPASNTPV RTVEGSPMMR AAMYSVEITV EKDKVTGETR
VLSSTTLLPR EPLLQGVKVY EDETKVVHAV DGTAVNGIQP LSSSEVDDLI HKADEVTLSE
AGPVAGAAET GGTSEEAVRT TTPSRREITG VQAQPGEATS GPPGIQPGQE PPVTMIFMGY
QNVEDEAESQ KVLGLQDTIT AELVVIGDEA EPKEAAPPNG SAAEPPTTSG SREENQVGPE
APASDTQDLD MKKQRCKCCS IM
//
