ID G1PYD3_MYOLU Unreviewed; 354 AA.
AC G1PYD3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Adenosine deaminase tRNA specific 3 {ECO:0000313|Ensembl:ENSMLUP00000016465.1};
GN Name=ADAT3 {ECO:0000313|Ensembl:ENSMLUP00000016465.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000016465.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000016465.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000016465.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC family. ADAT3 subfamily. {ECO:0000256|ARBA:ARBA00038160}.
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DR EMBL; AAPE02042147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PYD3; -.
DR SMR; G1PYD3; -.
DR STRING; 59463.ENSMLUP00000016465; -.
DR Ensembl; ENSMLUT00000017187.2; ENSMLUP00000016465.1; ENSMLUG00000017184.2.
DR eggNOG; KOG2771; Eukaryota.
DR GeneTree; ENSGT00390000010706; -.
DR HOGENOM; CLU_013817_2_1_1; -.
DR InParanoid; G1PYD3; -.
DR OMA; QHWPTSF; -.
DR OrthoDB; 1342940at2759; -.
DR TreeFam; TF313277; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd01285; nucleoside_deaminase; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR PANTHER; PTHR11079; CYTOSINE DEAMINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11079:SF156; INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED; 1.
DR Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 170..339
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
SQ SEQUENCE 354 AA; 38631 MW; 5FC6489CB8C8C229 CRC64;
MDPLGCTEQC EDKKAKSPNR EPALWQALPV LSEQQSRDVE LVLAYAAPIL DKRQTSRLLK
EVSAVHPLPA QPHLKRVRPS PDAGRPHVLE MLLCLAGPAA GTRSLAELLP HPAVDPRGLG
QPFLVPVPAW PPLTRGQFEE ARAHWPTSFH EDKHVTRALA GQLFSAQEQA EMQGHMERAI
RVAQQAATRG LRAVGAVVVD PASGQVLATG HDCSSSANPL LHATMVCIDL VAQGQGQGTY
DLRPHPACSF TPASASQDVQ AISMHTLDKD MDMDDNGLPY VCTGYDLYIT REPCAMCAMA
LVHSRVQRVF YGAPSPDGAL GTRFRIHARP DLNHRFQVFR GVLEAQCRQL DPDT
//
