ID G1PYU7_MYOLU Unreviewed; 243 AA.
AC G1PYU7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=KRAB domain-containing protein {ECO:0000259|PROSITE:PS50805};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000016629.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000016629.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000016629.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02055473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PYU7; -.
DR STRING; 59463.ENSMLUP00000016629; -.
DR Ensembl; ENSMLUT00000023378.1; ENSMLUP00000016629.1; ENSMLUG00000029978.1.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154693; -.
DR HOGENOM; CLU_002678_55_0_1; -.
DR InParanoid; G1PYU7; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF143; ZINC FINGER PROTEIN 747; 1.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 15..159
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
SQ SEQUENCE 243 AA; 27300 MW; E47FD927BB459115 CRC64;
MCKVRSMRSS ESQDMNFEDV AIAFSQEEWE LLDEAQRRLY CDVMLEVFTL VSFVGPWHKM
HDVEAYSEHS VSVGESQVRA SKTAAATQRT HLCKLCFSVL KDILHLSELQ VVHFEKNVFL
SDACVRDLCF SANPHQQQKD ASGEKPWKED MESALLVRSC CFYLSGMPAA SIQAGEDSPA
ISGLLQHQAT LNTEEPHSNN EITQEFLSGK RHHQWVECEA AASQKLKVAY QKGLCSGDMI
APL
//
