ID G1PYV4_MYOLU Unreviewed; 835 AA.
AC G1PYV4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=G protein-coupled receptor associated sorting protein 2 {ECO:0000313|Ensembl:ENSMLUP00000016636.1};
GN Name=GPRASP2 {ECO:0000313|Ensembl:ENSMLUP00000016636.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000016636.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000016636.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000016636.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GPRASP family.
CC {ECO:0000256|ARBA:ARBA00011013}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02007875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006084725.1; XM_006084663.2.
DR AlphaFoldDB; G1PYV4; -.
DR STRING; 59463.ENSMLUP00000016636; -.
DR Ensembl; ENSMLUT00000008238.2; ENSMLUP00000016636.1; ENSMLUG00000008246.2.
DR GeneID; 102417469; -.
DR KEGG; mlf:102417469; -.
DR eggNOG; ENOG502S6CE; Eukaryota.
DR GeneTree; ENSGT00940000162726; -.
DR HOGENOM; CLU_017437_0_0_1; -.
DR InParanoid; G1PYV4; -.
DR OMA; WPREEAN; -.
DR OrthoDB; 5256604at2759; -.
DR TreeFam; TF335652; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR043374; GASP1-3.
DR PANTHER; PTHR46414:SF1; G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 2; 1.
DR PANTHER; PTHR46414; PROTEIN BHLHB9-RELATED; 1.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 592..799
FT /note="Armadillo repeat-containing"
FT /evidence="ECO:0000259|Pfam:PF04826"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 835 AA; 93486 MW; F95FAB902488B017 CRC64;
MTGAEIEPST QAKPEKKAGE EVGGGTEREN DVQMVVRPKV RTQTQAMPGA RPKTESKAMN
GARPKTESKA VNGARPKTES QAMSGARRKT EPQAVVGARP KTEARAVGGA RPKTEAKAIP
GARLKDEAQA WAQAEFGAEA MSQTEGMPQT NAAAWPLVST ESGSVAKPIA LSVDRELVNV
DPETFPGSQG QSGIQPWFGS GEETNMGSWC YPRPRAREEA SNESGFWSAD EASTMSSLWA
GEEATIRSWP REEASTRSRH RAKHQPNPRS RTRSKQEPYV DSWSGSEEES GNPFCLWPGE
NANNLFRPRV RDEANAKSKL RTKKEDFFES ESEDEYYNES WFLPEEIINR FRPRDKEEPN
TALKPRAQKD DNSNKVKHEP KFEEDVIIGS WFWAEKEAGV EAGASAICES MSGAEEGAIG
GSLFWTEEKS SLGAVAREET RQESEEEAIF GSWFWDRDEA CFDLNPNPVY RASSRFRDLA
EEGINTASRP RTWEEVTVEY KSSPYRIGFP SPSSFRIPED ASSAFAELFV GKPNNAEGED
EESSPQADQL TLECEPSYRS VREIREHLRN RESAEPESWS CSCIQCELKI GSGEFEELLL
LMEKVRDPFI QEIYKIAMGT RSASQFTRDF IRDSGVVSLI ETLLDYPTSR VRTRFLENMI
LMAPPYPHLN MIETFICQVC EETFAQGLDS PEQLLGLRLL RHLTMTNDYH TLVANFMSEF
LSLLVTGDAT TKFYVLKMLL NMSENPVVAK TLFSTKALSV FVGLFTLQES HDNIQIVIKM
FQNINTIMRN GKAALIDDDF SPVPFMSAFH EFEKLAKALQ TQIDNQNDPD GGQPN
//
