ID G1Q1Q3_MYOLU Unreviewed; 793 AA.
AC G1Q1Q3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=TLR4 interactor with leucine rich repeats {ECO:0000313|Ensembl:ENSMLUP00000017636.1};
GN Name=TRIL {ECO:0000313|Ensembl:ENSMLUP00000017636.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017636.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000017636.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000017636.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02017986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1Q1Q3; -.
DR STRING; 59463.ENSMLUP00000017636; -.
DR Ensembl; ENSMLUT00000025663.1; ENSMLUP00000017636.1; ENSMLUG00000026172.1.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161975; -.
DR HOGENOM; CLU_357128_0_0_1; -.
DR InParanoid; G1Q1Q3; -.
DR OMA; PHDVLTY; -.
DR TreeFam; TF331598; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:Ensembl.
DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl.
DR GO; GO:0002718; P:regulation of cytokine production involved in immune response; IEA:Ensembl.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF307; TLR4 INTERACTOR WITH LEUCINE RICH REPEATS; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 679..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 341..397
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 393..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 793 AA; 86494 MW; 6F9144FDD00D75A6 CRC64;
PPWAQAVCPG AAATASTPKH LLCTNRGLRA VPKTSSLPSP QDVLTYSLGG NFITNITAFD
FHRLGQLRRL DLQYNQIRSL HPKTFEKLSR LEELYLGNNL LQALAPGTLA PLRKLRILYA
NGNEISRLSR GSFEGLESLV KLRLDGNALG ALPDAVFAPL GNLLYLHLES NRIRFLGKNA
FAQLGKLRFL NLSANELQPS LRHAATFAPL RSLSTLILSA NSLQHLGPRV FQHLPRLGLL
SLRGNQLANL APEAFWGLGA LRELRLERNR LSQLPAALLE PLHSLEALDL SGNELSALHP
TTFAHLGRLR ELSLRDNALS ALSGDIFAAS PALYRLDLDG NGWTCDCRLR GLKRWMGNWH
SQGRLLTVFV QCRHPPALRG KYLDYLDDQQ LQNGSCADPS PSVSPTGDAK RRPFPTATRE
KMAPPAGGLA KELPPQPQLQ PQQRERLPPG APWDGELLGN RSALRLSPWG PGLQQPGPSA
AAVAGPAPHP LDLQEKPQGG RPSPADPAHA EPTLPGTEAS APPPAGDLWQ RAAQQRLFPQ
QQESAAQADG GAVLPPLVSD PCDFNKLILC NLTVEAVGAD SASVRWAVRE HRSPRPLGGA
RFRLLFDRFG QQPKFHRFVY LPERSDSATL RELRGDTPYL VCVEGVLGGR VCPVAPRDHC
AGLVTLPEPG GRSGVDYQLL TLALLAVNAL LVLLALAAWA SRWLRRKLRA RRKGGAPVHV
RHMYSTRRPL RSMGTGVSAD FSGFQSHRPR TTVCALSEAD LIEFPCDRFM DSAGSGAGGS
LRREDHLLQR FAD
//
