ID G1Q2M2_MYOLU Unreviewed; 402 AA.
AC G1Q2M2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000017955.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000017955.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000017955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CLCR family.
CC {ECO:0000256|ARBA:ARBA00006398}.
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DR EMBL; AAPE02027643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1Q2M2; -.
DR STRING; 59463.ENSMLUP00000017955; -.
DR Ensembl; ENSMLUT00000030921.1; ENSMLUP00000017955.1; ENSMLUG00000026221.1.
DR eggNOG; ENOG502QRRD; Eukaryota.
DR GeneTree; ENSGT00940000160416; -.
DR HOGENOM; CLU_040707_1_0_1; -.
DR InParanoid; G1Q2M2; -.
DR OMA; HRPRVEN; -.
DR TreeFam; TF328396; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013642; CLCA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF2; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4; 1.
DR Pfam; PF08434; CLCA; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..402
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003419426"
FT DOMAIN 24..296
FT /note="Calcium-activated chloride channel N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08434"
FT DOMAIN 316..401
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
SQ SEQUENCE 402 AA; 45906 MW; 3BEDBC1333037A7C CRC64;
MVLFRSFVCL LVLYLLQGSD TSFVRLNNNG YEGIIIAINP GVPENEALIE KIKDMVTAAS
TYLFEATERR FFFKNVSILI PDTWKEKPQY KRPKHESYTH ADVLVAPPTL PDRDEPYTKQ
FKPCEEKGEY IHFTPDVVLG KKQNEYGPTD RLLVHEWAHL RWGVFDEYND DEPFYSASSK
RIEATRHDHL HFLQCSTGIT GVNRVYKCQG NSCVFNKCKI DPKTKLYEKN CQFFPDKDQT
EKTSIMFMQG ITSVVKFCNK QNHNEEAPSL QNKKCEFRST WEVISNSEDF KNTTPMVESP
PSPVFSLLRI RDRILCLVLD KSGSMGGYNR LNRMNQAAKY FLLQAVQNGT WVGMVHFDST
ANIKSKLIQI ISTNERNMLV NSLPTAASGG TSICAGIKAA FQ
//
