ID G1Q2W2_MYOLU Unreviewed; 4149 AA.
AC G1Q2W2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=PKHD1 like 1 {ECO:0000313|Ensembl:ENSMLUP00000018045.1};
GN Name=PKHD1L1 {ECO:0000313|Ensembl:ENSMLUP00000018045.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000018045.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000018045.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000018045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02009392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSMLUT00000024584.1; ENSMLUP00000018045.1; ENSMLUG00000013487.2.
DR GeneTree; ENSGT00940000157594; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 14.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 13.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR039448; Beta_helix.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF13229; Beta_helix; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF07691; PA14; 1.
DR Pfam; PF01833; TIG; 14.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 12.
DR SMART; SM00758; PA14; 1.
DR SMART; SM00710; PbH1; 10.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF49503; Cupredoxins; 1.
DR SUPFAM; SSF81296; E set domains; 14.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 334..493
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 2171..2291
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 3023..3161
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
SQ SEQUENCE 4149 AA; 455628 MW; B7D97F905ADC8283 CRC64;
EPYHHSFVHL SLSLCLPLPP PHGSKIIPKV TEIIPKYGSI NGATRLTIKG EGFAQANQFN
YGVDDAELGN TVQLVSSFRS ISCDVEKDAS HSTHITCYTR AMPEDSYTVR VSVDGVPVTE
NNTCRGLIHS RACSFYAKSF RTPTIRSITP LSGTPGTLIT IQGRIFTDVY GSNTARSSNG
KNVRILRVYI GGMPCELLIP QSDDLYGLKL DHPSGDMGSM ICKTTGTYIG HHNVSFILDN
DYGRSFPEKM AYFVSSLNKI SMFQTYAEIT MISPSQGSIQ GGTTLIISGR FFDQTDFPVR
VLVGGQACDV LNVTENTIYC KTSPKPDSLR TIHPGGRGLK LEVWNNSRPV HLEEILEYNE
KTPGYMGASW VDSASYVWPM EQDTFVARFS GFLVAPDSDV YRFYIKGDDR YAIYFSQTGL
PEDKNKIRIA YHSSNANSYF SSPTQRSDDI HLQKGKEYYI EILLQEYRLS AFVDVGLYQY
GNVYTEQQTE DAVNEEQVIQ SQSAIVQEVQ VITLENWETT NAIKEVQRIT VTSPCIEVSS
CSLYQYRLTY NMEKTGKCIQ ALLPADASDF LLQSALNDLW SLKPDTVQVT RTQNPQSYVY
TVTFISTRGD FDLLGYEVFE GYNVTLDIIE QTKGKPSLDT FTLNWDGITS KPLTPWSAEA
EFQAAVEEMV SAKCPPQIAD FEEGFVVKYF RDYENDFNMD HINRGQKTAE TDAYCGRYSL
KNPAVLFDSA DVKPNRLPYG DISLFPYNQT RLCLAYKGFL ADYIGLKFQY QDKSKITRST
DVQFTYSFAY GNNWTYTCID LLDLIQTKYT GTNFSLQRIS VQKASESQSF YVDIVYIGQT
PTISIWDEMP KRRLPALANK GIFLKHFQVN QTKSNGSSMT SQYSVTMTSY NCSYNIPMMA
VSFGQVITNE TENESVYRGN NWPGESRIRI QRIQAASAPL SGSFDIQAYG HVLKGLPAAV
SAADLQFALQ SLEGVGRVSV TREGTCAGYS WNIKWRSACG KQALLQVNDS NIIGEMANMT
VTKVKEGGLF RQRILGDLLR TPSQQPQVEV YVNGIPAKCS GDCGFTWDPM TTPIIRTISP
SKGSSEEGTI LTISGSGFSP SSAVSVSVGP IGCSLLSVNE NEIKCQILNG SAGHFPVAVS
IADVGLARNV EDKEFHFMYQ SQIAHIWPVS GSLAGGNLLT LSGTGFNENS KVLVGNETCN
VIDGDLNKIT CRTPKRIEGT VDISVITNGF QATAKDAYSY NCLQTPVITD FIPRVRTILG
ERNLTIKGYN FGTDLKQSME VYVGGKPCQI LHWNFTKIRC LLPTLSPGKH DIHVEVRNWG
FASTRDKLNA SIQYILEVNN VFPQRGSLYG GTEITIMGLG FSTIPTENTV LLGSFPCSVS
SSTSDVIKLH GLGYAWSPSV LNVSVGDTVT WHWQAHPFLT GIGYRVFSVS SPGSVTYDGK
GFMNGREKSA SGSFSYQFTS PGINYYSSGY VDEAHSIVLQ GVINVLPAES RHITLHLSVG
STEATYAQGE PVNLHVGSSV TGCLATEALC GLNNTGVKNS DKLLFELSSC FSPSISNISP
STGTVNELIT ITGHGFSNLT CANKVTIGSY PCVVEESSAN SIVCHIDPQN SMDVGIREIV
TLTVYNLGIA INTLPNEFDR RFVLLPNIDM VLPNAGSTTG MTKVTIKGSG FSVSSAAVEV
RMGRFPCEVL SVNYTTIECE TSPAPHQLVT VQLLIHGVPA QCQGNCSFSY SESIAASITS
ISPTSITGSV QALIEGEGFG TILEDIAVFI GNQQFRAVDV TDNNITVLVT PLPAGLHPVS
VVVGSKGLAL GNLSVSSPAV ASVRPTSGSI GGGTTLVITG NGFYPGNTTV TVGDESCQII
SVNASEVYCR TPAGAAGRVN VKIFVNAVAY PPLSFTYAWE DTPLLREIVP STGPPGTKIE
ITGSNFGTDI LEISVVINNI QCNVTMVNDS VLQCIVGDHA GGTFPVMMHR ETKGSAVSTL
VFEYPLTIHN IQPTQGSFGG GQMMTVTGTG FNPQNSEILV CGSECAVNRL KSDYTALLCK
IPPNNGRGPE QACEVSVANG KDLSRSTTPF TYTMSLTPLI TKIAPERGST AGGTRLTVMG
SGFSENTQDV RITIAETKCD VEYSNETCII CMTNAHTPSG WAPVRVTVGS MGMAKREKAD
FLYVDAWSSN CSWGGEPPPE EGSLVVIPKG QTVLLDQNTP VLKMLLIQGG TLIFDEADIE
LQAENILITD GGILQIGTEA SPFQHKAVIT LHGHLRSPEL PVYGAKTLAV REGVLDLHGL
PVPVVWTRLA HTAQAGERTL ILQEAVTWKP GDKIVVASTG HRHSQRENEE RTIEFVSADG
ISITLTHPLN YTHLGITVPL PDGTLFEARA EVGILTRNIL IRGSDNVEWH HKIPACPDGF
DTGEFATQTC LQGKFGEEIG SDQFGGCIMF HAPVPGANMV TGRIEYVEVF HAGQAFRLGR
YPIHWHLLGD LQFKSYVRGC AIHQTYNRAV TIHHTHHLLV ERNIIYDIKG GAFFIEDGIE
HGNILQYNLA VFVQQSTSLL NDDVTPAAFW VTNPNNTIRH NAAAGGTHFG FWYRMNDHPD
GPSYDRNICQ KRIPLGEFFN NTVHSQGWFG IWIFEEYFPM QTGSCTSTVP VPAIFNSLTT
WNCQKGAEWV NGGALQFHNF VMVNNYESGI ETKRILGAYI GGWGETNGAV IKNAKIVGHL
DELGMGPAFC TMRGLVLPFS EGLTVSSVHF MNFDRPNCVA LGVTSITGVC NERCGGWSAK
FADIQYFHTP NKAGFRWEHE VVLIDVDGSL TGHKGHTVIP HSSLLDPSHC TQEAEWSVGF
PGSVCDASVS FHRLAFNKPS PVSLLEKDVV LSDSFGTSIV PFRKKRLTHM SGWMALIPNA
KHINWYFKGV DHITNISYTS TFYGFKEEDY VIISHNFTQN PDMFNVIDMR NGSSNPLSWN
TSKNGDWHLE ANTSTLYYLV SGRNDLPQSQ PVSGNLDPDV KDVIINFQAY CCVLQDCFPV
HPPSRNPIPR KRPATYNLWS NDSFWQSSRE NNYTIPHPGA NVVIPEGTWV VADTDIPPLE
RLIIWGVLEL EDKHNVEAAE SSYRKVVLNA TYISLQGGRL IGGWEDNPFK GELQIVLRGN
HSTPEWAFPE GPNQGSKVLG VFGELDLHGL PRSIYKTKLS ETAEAGSKVL SLMDAVDWQE
GEEIVITTTS YDIHQTETRS IAKILHGHKI LILNEPLSYT HLGERYQVPG TRQSYTLAAD
VGILSRNIKI LGEDYPGWFQ ESFGARVLIS SFTENMMTFK GNARISDVEF YHSGQEGFRD
STDPRYAVTF LNLGQIQERG SSYIRGCAFH HGFSPAIGVF GTDGLDIEDN IIHFTVGEGI
RIWGDANRVR GNLVALSVWP GTYQNRKDLS STLWHAAIEI NRGTNTVLQN NVVAGFGRAG
YRIDGEPCSS LSNPLEKWSD NEAHGGLYGI YMNQDGLPGC SLIQGFTIWM CWDYGIYFQT
TESVYIHNVT LVDNGMAISS MIYMPAAISH QISNKTVQIK SSLIVGSSPE FNCSDLLTND
DPNIELSAAH RSSRPPSGGR SGICWPTFAS AHNMAPRKPH AGIMSYNAIS GLLDVSGSTF
VGFKNVCSGE TNVIFITNPL NEDLQHPIHV KNIQLVDTIE KAKIFIHRPD IRKVNPSDCV
DMVCDAKRKS FLRDMDGSFL GNSGSVIPQS EYEWNGNSQF GIGDYRIPKV MLTFPNGSRI
PVTEKAPYKG IIRDSACRYI PEWQSYRCFG MEYAMMVIES LDSDTETRRL SPVAIVSSGY
VDLINDLGPQ DHGWCAGYSC QRRLSLFHSI VALNKSYEVY FTGTSPQNLR LMLLNVKHDK
AVLVGIFFST LQRLDVYVNN ALVCPKDTVW NPQQKHCEFN RHLHTEQFLP NLNSTVLGEN
YFDRTYQMLY LLVKGTMPVE IHTTAVIFVS FQIPAVTEED FYSSHNLVRN LALFLKIPSD
KIRISKVIGG DSVRKKRSMG LTVQLEIGDP PPQFITNDTT AGQMQLSELQ EVAASLGQAV
ILGKTSSTLG FNVSSMSLIN PIPSSSDSEW IKVTAQPVER FAFLVHHVAV VSSLSVISQP
VAAQLGQPLS QQPSVKAVDP DGNCVSVGIT SLTLKAILKD SNNNQISGLG GNTTIPFSSY
WANYTDLTL
//
