ID G1Q493_MYOLU Unreviewed; 1162 AA.
AC G1Q493;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Anaphylatoxin-like domain-containing protein {ECO:0000259|PROSITE:PS01178};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000018526.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000018526.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000018526.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AAPE02055121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1Q493; -.
DR STRING; 59463.ENSMLUP00000018526; -.
DR Ensembl; ENSMLUT00000027080.1; ENSMLUP00000018526.1; ENSMLUG00000025532.1.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000154063; -.
DR HOGENOM; CLU_001634_4_0_1; -.
DR InParanoid; G1Q493; -.
DR OMA; TESDNEM; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR CDD; cd00017; ANATO; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR049466; C3_CUB1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF81; COMPLEMENT C3; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21406; C3_CUB1; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
PE 4: Predicted;
KW Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1162
FT /note="Anaphylatoxin-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417916"
FT DOMAIN 692..727
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
SQ SEQUENCE 1162 AA; 129226 MW; 935A25D18A6F2413 CRC64;
MGPASGPSLL LLLSCLPLAL GDPMFSIITP NILRLENEET VVLEAHGGTG NIPVKVTVHD
FPAKKQVLSS EDTILNSANG YLSTVTIKIP ASKELKSQKN KFVTVQAVFG KVSVEKVVLV
SLQSGYLFIQ TDKTIYTPGS TVLYRIFTVD HKLLPANQKV IVSIETPEGI PIKRDFLSSQ
NHIGILSLSW NIPELVNMGQ WKIKAHYEDS PQQVFSAEFE VKEYVLPSFE VQVEPAEKFY
YIDDPKGLEV TITARFLYGK NVDGTAFVIF GVQDGDQRIS LSQSLTRVVI EDGTGEAVLS
REVLLSAAPQ APREAALVGK SLYVSVTVIL HSGSDMVEAE RSGIPIVTSP YQIHFTKTPR
FFKPTMPFDL MVYVTNPDGS PAPRIPVAIQ GSNQEISVTR DDGLAKLTIN THKSLKPLLI
TVRTMKEGLP EGRQATSQMQ AIPYSTMGNS NNYLHLSIPA TELKPGDKLN VNFVLQMDPG
QDANIRYFTY LVMNKGKLLK VGRQVREPGQ VLVVLPLTIT TEFIPSFRLV AYYTLNKGGQ
REVVADSVWV DVKDSCVGTL VVKSAMKEEK HQHLPGQQIS LKIEGNQGAR VGLVAVDKGV
FVLNKKNRFT QKTIWDTVEK ADIGCTPGSG KNYAGVFTDA GLAFQTSKGL QTEQRSDLAC
PKPATRRRRS VQLMEKRKGK AGEYPSKELR KCCEDGMREN PMQYPCQCRA QFILQDKACV
DAFLDCCNYI TQQRLEHSRD SDLGLARSDL DEEIIPEEDI VSRSQFPESW LWTIEELKDP
EKNGISSKTI KVFLKDSITT WEIMAVSLSD RKGICVADPY EVTVVQDFFI DLRLPYSVVR
NEQVEIRAVL YNYREADTLT VRVEMLYNPA FCSLATAKKR HLQTVTIPPK SSLAVPYVIV
PLVVGLQEVE VKATVYRHFF TDGVRKTLKV VPEGIRMNKT VAVKTLDPQH LGQNGVQRVE
VEAADLSDQV PDTESETRIL LQGTPVAQMA EDAIDGQQLG HLIQVPWGCG EQNMIYMTPT
VIAVHYLDHS EQWDKFGIDK RQEALDLIKK GYTQQLSYRH PNKAFAAYQS RKSSTWLTAY
VVKVFSLATN LIAIDSEVIC GAIKWLILEK QRPDGVFQED SPVGQLQMTG GLNDAEEKDV
SLTAFVLIAL QEAKDICEGQ VN
//
