ID G1Q652_MYOLU Unreviewed; 77 AA.
AC G1Q652;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Apelin {ECO:0000256|ARBA:ARBA00020395};
DE AltName: Full=APJ endogenous ligand {ECO:0000256|ARBA:ARBA00030305};
GN Name=APLN {ECO:0000313|Ensembl:ENSMLUP00000019185.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000019185.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000019185.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000019185.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the apelin family.
CC {ECO:0000256|ARBA:ARBA00008623}.
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DR EMBL; AAPE02002285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014314134.1; XM_014458648.1.
DR AlphaFoldDB; G1Q652; -.
DR STRING; 59463.ENSMLUP00000019185; -.
DR Ensembl; ENSMLUT00000028116.1; ENSMLUP00000019185.1; ENSMLUG00000023749.1.
DR GeneID; 102430779; -.
DR KEGG; mlf:102430779; -.
DR CTD; 8862; -.
DR eggNOG; ENOG502S9TY; Eukaryota.
DR GeneTree; ENSGT00390000014020; -.
DR HOGENOM; CLU_198461_0_0_1; -.
DR InParanoid; G1Q652; -.
DR OMA; GHRQNGW; -.
DR OrthoDB; 4641267at2759; -.
DR TreeFam; TF339660; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031704; F:apelin receptor binding; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:Ensembl.
DR GO; GO:0060183; P:apelin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:1904706; P:negative regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:1904022; P:positive regulation of G protein-coupled receptor internalization; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:1905564; P:positive regulation of vascular endothelial cell proliferation; IEA:Ensembl.
DR InterPro; IPR026155; Apelin.
DR PANTHER; PTHR15953; APELIN; 1.
DR PANTHER; PTHR15953:SF0; APELIN; 1.
DR Pfam; PF15360; Apelin; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Gastrulation {ECO:0000256|ARBA:ARBA00023218};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..77
FT /note="Apelin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003419624"
FT REGION 28..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 77 AA; 8545 MW; 609BAC8C73605721 CRC64;
MNLRLCVQAL LLLWLSLTSV CGGPLPQPSA GKGLEEGNIH HLVQPRGSRN GPGPWQGGRR
KFRRQRPRLS HKGPMPF
//
