ID G1Q6J3_MYOLU Unreviewed; 599 AA.
AC G1Q6J3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=REC8 meiotic recombination protein {ECO:0000313|Ensembl:ENSMLUP00000019326.1};
GN Name=REC8 {ECO:0000313|Ensembl:ENSMLUP00000019326.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000019326.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000019326.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000019326.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad21 family.
CC {ECO:0000256|ARBA:ARBA00009870}.
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DR EMBL; AAPE02044606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1Q6J3; -.
DR STRING; 59463.ENSMLUP00000019326; -.
DR Ensembl; ENSMLUT00000023471.1; ENSMLUP00000019326.1; ENSMLUG00000026414.1.
DR eggNOG; KOG1213; Eukaryota.
DR GeneTree; ENSGT00390000011379; -.
DR HOGENOM; CLU_036680_0_0_1; -.
DR InParanoid; G1Q6J3; -.
DR OMA; RVYFQQC; -.
DR TreeFam; TF338144; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0030893; C:meiotic cohesin complex; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
DR GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR GO; GO:0007130; P:synaptonemal complex assembly; IEA:Ensembl.
DR CDD; cd21794; Rad21_Rec8_M_Rec8; 1.
DR InterPro; IPR039781; Rad21/Rec8-like.
DR InterPro; IPR006909; Rad21/Rec8_C_eu.
DR InterPro; IPR006910; Rad21_Rec8_N.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12585:SF27; MEIOTIC RECOMBINATION PROTEIN REC8 HOMOLOG; 1.
DR PANTHER; PTHR12585; SCC1 / RAD21 FAMILY MEMBER; 1.
DR Pfam; PF04824; Rad21_Rec8; 1.
DR Pfam; PF04825; Rad21_Rec8_N; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 1..110
FT /note="Rad21/Rec8-like protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04825"
FT DOMAIN 542..598
FT /note="Rad21/Rec8-like protein C-terminal eukaryotic"
FT /evidence="ECO:0000259|Pfam:PF04824"
FT REGION 165..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..331
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 68245 MW; E9380DB0A9A869A5 CRC64;
MFYYPNVLQR HTGCFSTIWL AATRGSRLVK REYLKVNVVK TCEEILSYVL VQVQPSQPGL
PRPRFSLYLS AQLQIGVIRV YSQQCQYLVE DIQHILERLH RAQLQIRIDM VETELPSLLL
PNCLAMMETL EDAPDPFFGM MSVDPRLPSP FDIPQIRHLL EAVTPERVPE ETPPEVPREP
GKPDRTPVTV LSPEAITLQE AEPIRMLQID GERDLPEVSR RDLDLLIAEE DEAILLEEQG
RPVHQCGTCL VLDMSKEEPR APEVETIVPP LSPLALPQVE EAAEPLPGQV LAPEEVKPAV
WEPEALLAEV TPPPPQELHL PAPLSPERRP PAAPPARRRR SRRRQLLFWD KETQISRENF
QKQLQTRAHC WECPMVQPPE RIIRSPAELF QTPTYSGWLP PELLAFWTRC AQLPPKALRR
MPLEPEEEAA EREAAAEEER RKTETLSDIE VLREAQEPSG PLMLSSELSI EAAEEEKSHI
SLIPPEERWA WAEAEQPEPP VLPVVPELPE VPMEMPLELP PEAELLSLEA VYRAVAQELQ
ANRKPDFSSL VSPLSPRRMA ARVFYLLLAL TVLAAQQIFR MEQEKPYGRL LIQPGPRFQ
//
