ID G1Q9F3_MYOLU Unreviewed; 652 AA.
AC G1Q9F3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Dystrotelin {ECO:0000313|Ensembl:ENSMLUP00000020336.1};
GN Name=DYTN {ECO:0000313|Ensembl:ENSMLUP00000020336.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000020336.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000020336.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000020336.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02003239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1Q9F3; -.
DR STRING; 59463.ENSMLUP00000020336; -.
DR Ensembl; ENSMLUT00000028136.1; ENSMLUP00000020336.1; ENSMLUG00000028179.1.
DR eggNOG; KOG4286; Eukaryota.
DR GeneTree; ENSGT00940000162403; -.
DR InParanoid; G1Q9F3; -.
DR OMA; SWVQSEP; -.
DR TreeFam; TF326090; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16243; EFh_DYTN; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF18; DYSTROTELIN; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 220..276
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 448..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 73780 MW; 96F67A83F3857D9E CRC64;
PSRIDALNSI ENSIYRTAFK LRSVQTTCQL DLIGSSQIQH VLLCPSFWEA RESPLSVQHL
FQALQELFQR AREKPGQVHP GAAELTLSLL MAMYDSTGTG FLKLTPAAAA LIALSGDSPL
TKYRALFQLY AENKRGGYDS GARMTRRTLR NLLTDLQQIP TVVGESRSLC SVESATRSCF
QGVLSPAIKE EKFLSWLQSE PPILLWLPTC YRLSATEMAT HPARCGVCRS FPITGLRYRC
LKCLNFDICQ MCFLSGLHSK SHQTSHPVVE HCVQEMSAKE YTRLLLGTLR SNLLQECWRR
KEAARRQWLL DQVKAKAAAG RAQARLSIQY PIGPVETAAM KASKRICQRM SQAQQTDDSS
PHHQATVSIR NELWRTHEYI NALHRERRFL KKQLNRYKDK LQAIYTSQEE KCCRFETKIH
ELTANQDSLW TKLQQMGQDL QAKFQPLHPS SYQNMISKSD HEKDKSFWKE EDSSQSKNAS
ADGPEWEPFL NPPVVDKSQQ SQAKVEHALP NSESPEAILQ PTSTQSTRAQ SQAQKTAKEI
FSSPTGPQEG LLQDTPQNAP TEIHSPTLPP MERKETVNIQ EEKDELEEEE LQELLSKLMD
AFTLEMPPDP QPSVNTDLYR GAERVSRAFS ALVDQITLPN WEKESGLKGP WG
//
