ID G1QFN1_MYOLU Unreviewed; 775 AA.
AC G1QFN1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
GN Name=CNNM4 {ECO:0000313|Ensembl:ENSMLUP00000022514.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022514.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022514.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000022514.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC ECO:0000256|RuleBase:RU369091}.
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DR EMBL; AAPE02045598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QFN1; -.
DR STRING; 59463.ENSMLUP00000022514; -.
DR Ensembl; ENSMLUT00000030880.1; ENSMLUP00000022514.1; ENSMLUG00000024378.1.
DR eggNOG; KOG2118; Eukaryota.
DR GeneTree; ENSGT00940000156317; -.
DR HOGENOM; CLU_011310_1_1_1; -.
DR InParanoid; G1QFN1; -.
DR OMA; ESMKLYA; -.
DR TreeFam; TF101012; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0070166; P:enamel mineralization; IEA:Ensembl.
DR GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:Ensembl.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:Ensembl.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF26; METAL TRANSPORTER CNNM4; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..775
FT /note="Metal transporter"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003419225"
FT TRANSMEM 182..206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 240..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT DOMAIN 178..358
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 445..511
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 575..654
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 775 AA; 86847 MW; 59B1F4606D9F4011 CRC64;
HGPAGGGGRP GGGPARGRLL LVALVLPVLL WARGVRGQGD PQRSTILGMR LESCDKPCGM
NPNGIIFVSE GSTVNLRLYG HRLGSISSNL ISFSEVDNSE ALHNSTHCPE LTKDLVVQQL
VNVSRGDTSG MLVVFTKFLR RSENMKLYAL CTRASVDGPW QRWTDKDSLL YMVEEAGRFL
PLWLHILIIL VLLVLSGIFS GLNLGLMALD PMELRIVQNC GTEKERRYAR KIEPIRRKGN
YLLCSLLLGN VLVNTSLTIL LDNLIGSGLM AVASSTIGIV IFGEILPQAL CSRHGLAVGA
NTIVLTKFFM LLTFPLSFPI SKLLDFFLGQ EIHTVYNREK LMEMLKVTEP YNDLVKEELN
MIQGALELRT KTVEDIMTQL HDCFMIRNDA ILDFNTMSEI MESGYTRIPV FEDEQSNIVD
ILYVKDLAFV DPDDCTPLKT ITRFYNHPVH FVFHDTKLDA MLEEFKKGKS HLAIVQKVNN
EGEGDPFYEV LGLVTLEDVI EEIIKSEILD ESDMYTDNRS RKRVAEKNKR DFSAFKDTDN
ELKVKISPQL LLAAHRFLST EVPQFSPALI SEKILLRLLK YPDVIQELKF DEHNKYYVHH
YLYTRNKPAD YFILILQGKV EVEAGKENMK FETGAFSYYG TMALSSLTTD RSPSHPTCLS
RSASLSCPDR TDLSSPAPLA GSSNQLGSSV LGQYISDFSV RALMDLQYIK ITRQQYQNGL
LASRMETSPQ FPLDGCTICT ENLAEKPELP VVDETTTLLN ERNATLHRAS PESAI
//
