ID G1QIV7_NOMLE Unreviewed; 252 AA.
AC G1QIV7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000000851.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000000851.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000000851.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; ADFV01123973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01123974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01123975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01123976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01123977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QIV7; -.
DR STRING; 61853.ENSNLEP00000000851; -.
DR Ensembl; ENSNLET00000000907.2; ENSNLEP00000000851.2; ENSNLEG00000000737.2.
DR eggNOG; KOG4792; Eukaryota.
DR GeneTree; ENSGT00820000127055; -.
DR HOGENOM; CLU_060542_0_1_1; -.
DR InParanoid; G1QIV7; -.
DR OMA; QHNPEDD; -.
DR TreeFam; TF321436; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
DR GO; GO:0045309; F:protein phosphorylated amino acid binding; IEA:Ensembl.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0098749; P:cerebellar neuron development; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0016358; P:dendrite development; IEA:Ensembl.
DR GO; GO:0007167; P:enzyme-linked receptor protein signaling pathway; IEA:Ensembl.
DR GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
DR GO; GO:0035685; P:helper T cell diapedesis; IEA:Ensembl.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0035022; P:positive regulation of Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:1904395; P:positive regulation of skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
DR GO; GO:0098698; P:postsynaptic specialization assembly; IEA:Ensembl.
DR GO; GO:0038026; P:reelin-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0050773; P:regulation of dendrite development; IEA:Ensembl.
DR GO; GO:2000404; P:regulation of T cell migration; IEA:Ensembl.
DR CDD; cd11759; SH3_CRK_C; 1.
DR CDD; cd11758; SH3_CRK_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035458; CRK_SH3_C.
DR InterPro; IPR035457; CRK_SH3_N.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF8; ADAPTER MOLECULE CRK; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 80..140
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 183..244
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 149..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 252 AA; 28412 MW; 00E04ED714FC7C6F CRC64;
KKFSWAWWRE PVILAIQEAE TGESLEPGRQ SPSRLRIGDQ EFDSLPALLE FYKIHYLDTT
TLIEPVSRSR QGSGVTLRQE EAEYVRALFD FNGNDEEDLP FKKGDILRIR DKPEEQWWNA
EDSEGKRGMI PVPYVEKYRP ASASVSALIG GNQEGSHPQP LGGPEPGPYA QPSVNTPLPN
LQNGPIYARV IQKRVPNAYD KTALALEVGE LVKVTKINVS GQWEGECNGK RGHFPFTHVR
LLDQQNPDED FS
//
