ID G1QJ12_NOMLE Unreviewed; 545 AA.
AC G1QJ12;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Cyclin K {ECO:0000313|Ensembl:ENSNLEP00000000906.2};
GN Name=CCNK {ECO:0000313|Ensembl:ENSNLEP00000000906.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000000906.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000000906.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000000906.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR EMBL; ADFV01087173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01087174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01087175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01087176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01087177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01087178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01087179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01087180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01087181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QJ12; -.
DR STRING; 61853.ENSNLEP00000000906; -.
DR Ensembl; ENSNLET00000000963.2; ENSNLEP00000000906.2; ENSNLEG00000000753.2.
DR eggNOG; KOG0834; Eukaryota.
DR GeneTree; ENSGT00940000156384; -.
DR HOGENOM; CLU_022000_0_2_1; -.
DR InParanoid; G1QJ12; -.
DR OMA; FVIACCR; -.
DR TreeFam; TF101010; -.
DR Proteomes; UP000001073; Chromosome 22a.
DR GO; GO:0002944; C:cyclin K-CDK12 complex; IEA:Ensembl.
DR GO; GO:0002945; C:cyclin K-CDK13 complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0008353; F:RNA polymerase II CTD heptapeptide repeat kinase activity; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0044828; P:negative regulation by host of viral genome replication; IEA:Ensembl.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd20530; CYCLIN_CCNK_rpt1; 1.
DR CDD; cd20531; CYCLIN_CCNK_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF51; CYCLIN-K; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF21797; CycT2-like_C; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 55..149
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 158..278
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT DOMAIN 162..256
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 262..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..374
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..425
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..535
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 60561 MW; 779827836539967B CRC64;
MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR REGARFIFDV
GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL FLAGKVEETP KKCKDIIKTA
RSLLNDVQFG QFGDDPKEEV MVLERILLQT IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK
LVQMAWTFVN DSLCTTLSLQ WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ
DVPVDVLEDI CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPQVQQ SQPSQSSEPS
QPQQKDPQQP AQQQQPAQQP KKPSPQPSSP RQVKRAVVSG LKQALEPPPP KIPKIETTHP
PLPPAHPPPD RKPPLAAALG EAEPPGPVDA TDLPKVQIPP PAHPAPVHQP PPLPHRPPPP
PPSSYMTGMS TTSSYMSGEG YQSLQSMMKT EGPSYGALPP AYGPPAHLPY HPHVYPPNPP
PPPVPPPPAS FPPTFPPHPP PGLGLPPASY PPPAVPPGGQ PPVPPPIPPP GMPPVGGLGR
AAWMR
//
