ID G1QKS6_NOMLE Unreviewed; 449 AA.
AC G1QKS6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Cyclic GMP-AMP synthase {ECO:0000313|Ensembl:ENSNLEP00000001525.3};
GN Name=CGAS {ECO:0000313|Ensembl:ENSNLEP00000001525.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000001525.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000001525.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000001525.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the mab-21 family.
CC {ECO:0000256|ARBA:ARBA00008307}.
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DR EMBL; ADFV01063806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01063807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01063808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01063809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01063810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01063811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01063812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01063813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01063814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QKS6; -.
DR Ensembl; ENSNLET00000001613.3; ENSNLEP00000001525.3; ENSNLEG00000001281.3.
DR eggNOG; KOG3963; Eukaryota.
DR GeneTree; ENSGT01050000244827; -.
DR HOGENOM; CLU_040428_2_0_1; -.
DR Proteomes; UP000001073; Chromosome 3.
DR Gene3D; 1.10.1410.40; -; 1.
DR Gene3D; 3.30.460.90; -; 1.
DR InterPro; IPR024810; Mab-21-like.
DR InterPro; IPR046903; Mab-21-like_nuc_Trfase.
DR InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR PANTHER; PTHR10656:SF35; CYCLIC GMP-AMP SYNTHASE; 1.
DR Pfam; PF03281; Mab-21; 1.
DR Pfam; PF20266; Mab-21_C; 1.
DR SMART; SM01265; Mab-21; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 215..391
FT /note="Mab-21-like nucleotidyltransferase"
FT /evidence="ECO:0000259|Pfam:PF03281"
FT DOMAIN 407..447
FT /note="Mab-21-like HhH/H2TH-like"
FT /evidence="ECO:0000259|Pfam:PF20266"
FT REGION 1..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..145
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 49887 MW; 4B9A17285B4A04F1 CRC64;
LKSWHGKAMR RDSEAGATAS EASARSARGA PTDPNESPAA PEAALPKAGK FGPARKSGSR
QKKSAPDTQE RPPVRATGAR AKKAPQRAQD AQPSDATSAP GAEGLEPPAA REPALSRAGS
RHQRGARCSP KPRPPPGPGD VPSPGLPVSD PILVQGDAAP GARKLRAVLE KLKLSRQEIS
EAAEVVNGVV DHLLRRLQKC DSEFRGVGLL RTGSYYEHVK ISAPNEFDVM FKLEVPRIQL
EEYSNTGAYY FVKFKRNPKE NPLSQFLEGE ILSASKMLSK FRKIIKEEIN NIKDTDVIMK
RKRGGSPAVT LLISEKISVD ITLALESNSN SWPASTQEGL PIKDWLSGKV RRQLRLKPFY
LVPKHAKEGN GFQEETWRLS FSHIEKEILN NHGKTKTCCE NKNVKCCRKD CLKLMKYLLE
QLKERFKDKK HLDKFSSYHV KTAFFHRLY
//
