GenomeNet

Database: UniProt
Entry: G1QLG5_NOMLE
LinkDB: G1QLG5_NOMLE
Original site: G1QLG5_NOMLE 
ID   G1QLG5_NOMLE            Unreviewed;       321 AA.
AC   G1QLG5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 3.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=L-gulonate 3-dehydrogenase {ECO:0000256|ARBA:ARBA00038962};
DE            EC=1.1.1.45 {ECO:0000256|ARBA:ARBA00038962};
DE   AltName: Full=L-gulonate 3-dehydrogenase {ECO:0000256|ARBA:ARBA00042709};
GN   Name=CRYL1 {ECO:0000313|Ensembl:ENSNLEP00000001780.3};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000001780.3, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000001780.3, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000001780.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009463}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADFV01116990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01116999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1QLG5; -.
DR   STRING; 61853.ENSNLEP00000001780; -.
DR   Ensembl; ENSNLET00000001883.3; ENSNLEP00000001780.3; ENSNLEG00000001458.3.
DR   eggNOG; KOG2305; Eukaryota.
DR   GeneTree; ENSGT00390000007182; -.
DR   HOGENOM; CLU_009834_0_0_1; -.
DR   InParanoid; G1QLG5; -.
DR   OMA; RDNCLTH; -.
DR   TreeFam; TF313501; -.
DR   Proteomes; UP000001073; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0050104; F:L-gulonate 3-dehydrogenase activity; IEA:Ensembl.
DR   GO; GO:0070403; F:NAD+ binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:0019640; P:glucuronate catabolic process to xylulose 5-phosphate; IEA:Ensembl.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          17..190
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          194..282
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   SITE            147
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ   SEQUENCE   321 AA;  35915 MW;  4E607C95352DD997 CRC64;
     ELILFYGCLV FHGVYVGVIG RSWAMLFASG GFQVKLYDIE QQQIRNALES IRKEMKLLEQ
     AGSLKGSLSV EEQLSLISGC PNIQEAVEGA MHIQECVPED LELKKKIFAQ LDSIIDDQVI
     LSSSTSCLMP SKLFAGLVHV KQCIVAHPVN PPYYIPLVEL VPHPETAPTT VDRTHALMKK
     IGQCPMRVQK EVAGFVLNRL QYAIIGEAWR LVEEGIVSPS DLDLVMSEGL GMRYAFIGPL
     ETMHLNAEGM LSYCDRYSEG MKHVLKTFGP IPEFSRATAE KVNQDMCMKV PGDPEHLAAR
     RQWRDECLMR LAKLKSQVQP Q
//
DBGET integrated database retrieval system