ID G1QLG5_NOMLE Unreviewed; 321 AA.
AC G1QLG5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=L-gulonate 3-dehydrogenase {ECO:0000256|ARBA:ARBA00038962};
DE EC=1.1.1.45 {ECO:0000256|ARBA:ARBA00038962};
DE AltName: Full=L-gulonate 3-dehydrogenase {ECO:0000256|ARBA:ARBA00042709};
GN Name=CRYL1 {ECO:0000313|Ensembl:ENSNLEP00000001780.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000001780.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000001780.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000001780.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
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DR EMBL; ADFV01116990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01116999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QLG5; -.
DR STRING; 61853.ENSNLEP00000001780; -.
DR Ensembl; ENSNLET00000001883.3; ENSNLEP00000001780.3; ENSNLEG00000001458.3.
DR eggNOG; KOG2305; Eukaryota.
DR GeneTree; ENSGT00390000007182; -.
DR HOGENOM; CLU_009834_0_0_1; -.
DR InParanoid; G1QLG5; -.
DR OMA; RDNCLTH; -.
DR TreeFam; TF313501; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0050104; F:L-gulonate 3-dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0070403; F:NAD+ binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:0019640; P:glucuronate catabolic process to xylulose 5-phosphate; IEA:Ensembl.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 17..190
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 194..282
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 147
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 321 AA; 35915 MW; 4E607C95352DD997 CRC64;
ELILFYGCLV FHGVYVGVIG RSWAMLFASG GFQVKLYDIE QQQIRNALES IRKEMKLLEQ
AGSLKGSLSV EEQLSLISGC PNIQEAVEGA MHIQECVPED LELKKKIFAQ LDSIIDDQVI
LSSSTSCLMP SKLFAGLVHV KQCIVAHPVN PPYYIPLVEL VPHPETAPTT VDRTHALMKK
IGQCPMRVQK EVAGFVLNRL QYAIIGEAWR LVEEGIVSPS DLDLVMSEGL GMRYAFIGPL
ETMHLNAEGM LSYCDRYSEG MKHVLKTFGP IPEFSRATAE KVNQDMCMKV PGDPEHLAAR
RQWRDECLMR LAKLKSQVQP Q
//